Search results
Results from the WOW.Com Content Network
The epithelial–mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell–cell adhesion, and gain migratory and invasive properties to become mesenchymal stem cells; these are multipotent stromal cells that can differentiate into a variety of cell types.
Unlike epithelial cells – which are stationary and characterized by an apico-basal polarity with binding by a basal lamina, tight junctions, gap junctions, adherent junctions and expression of cell-cell adhesion markers such as E-cadherin, [4] mesenchymal cells do not make mature cell-cell contacts, can invade through the extracellular matrix, and express markers such as vimentin ...
Neural mesenchyme soon undergoes a mesenchymal–epithelial transition under the influence of WNT6 produced by ectoderm to form somites. [20] These structures will undergo a secondary EMT as the somite tissue migrates later in development to form structural connective tissue such as cartilage and skeletal muscle. [21]
During the epithelial–mesenchymal transition (EMT), the primary mesenchyme cells (PMCs) detach from the epithelium and become internalized mesenchyme cells that can migrate freely. [ 1 ] While the mechanisms of ingression are not fully understood, studies using the sea urchin as a model organism have begun to shed light on this developmental ...
During gastrulation, migrating epiblast cells undergo epithelial-mesenchymal transition in order to lose cell-cell adhesion , delaminate from the epiblast layer and migrate over the dorsal surface of the epiblast then down through the primitive streak. The first wave of epiblast cells to invaginate through the primitive streak invades and ...
In epithelial tumors, the epithelial-mesenchymal transition (EMT) is considered to be a crucial event. [84] EMT and the reverse transition from mesenchymal to an epithelial phenotype are involved in embryonic development, which involves disruption of epithelial cell homeostasis and the acquisition of a migratory mesenchymal phenotype. [85]
The epithelial-mesenchymal transition is a mechanism during which the tumor cell detaches from the epithelial layer and gains motility, the "locomotor phenotype," which promotes invasive growth and metastasis.
Epithelial–mesenchymal transition and intravasation [ edit ] Epithelial–mesenchymal transition (EMT) has been hypothesized to be an absolute requirement for tumor invasion and metastasis, [ 1 ] although both EMT and non-EMT [ clarification needed ] cells have been shown to cooperate to complete the spontaneous metastasis process. [ 1 ]