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  2. Epithelial–mesenchymal transition - Wikipedia

    en.wikipedia.org/wiki/Epithelialmesenchymal...

    The epithelial–mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell–cell adhesion, and gain migratory and invasive properties to become mesenchymal stem cells; these are multipotent stromal cells that can differentiate into a variety of cell types.

  3. Mesenchymal–epithelial transition - Wikipedia

    en.wikipedia.org/wiki/Mesenchymalepithelial...

    Unlike epithelial cells – which are stationary and characterized by an apico-basal polarity with binding by a basal lamina, tight junctions, gap junctions, adherent junctions and expression of cell-cell adhesion markers such as E-cadherin, [4] mesenchymal cells do not make mature cell-cell contacts, can invade through the extracellular matrix, and express markers such as vimentin ...

  4. Wnt signaling pathway - Wikipedia

    en.wikipedia.org/wiki/Wnt_signaling_pathway

    Wnt signaling is involved in another key migration process known as the epithelial-mesenchymal transition (EMT). This process allows epithelial cells to transform into mesenchymal cells so that they are no longer held in place at the laminin. It involves cadherin down-regulation so that cells can detach from laminin and migrate.

  5. Collective cell migration - Wikipedia

    en.wikipedia.org/wiki/Collective_cell_migration

    Similar to collective cell migration in development and wound healing, cancer cells also undergo epithelial to mesenchymal transition (EMT), that reduces cell-cell adhesions and allows cancer spreading. [20] The diagram on the right shows: A: Border cell migration in a Drosophila embryo. (a) shows border cells migrating in a confined space ...

  6. Cancer stem cell - Wikipedia

    en.wikipedia.org/wiki/Cancer_stem_cell

    Stationary cancer stem cells are embedded in early carcinomas and these cells are detectable in the differentiated central area of a tumor. The important step toward malignancy is the induction of epithelial mesenchymal transition (EMT) in the stationary cancer stem cells (SCS), which become mobile or migrating cancer stem cells.

  7. Vasculogenic mimicry - Wikipedia

    en.wikipedia.org/wiki/Vasculogenic_mimicry

    This is a mechanism through which cancer cells lose their epithelial properties resulting in a loss of cell-cell adhesion and a transition towards mesenchymal-like properties . EMT plays a diverse and essential role in adhesion, motility and morphology of cells under both normal and pathological conditions.

  8. Circulating tumor cell - Wikipedia

    en.wikipedia.org/wiki/Circulating_Tumor_Cell

    Cytokeratin-negative CTCs are characterised by the lack of EpCAM or cytokeratins, which may indicate an undifferentiated phenotype (circulating cancer stem cells) or the acquisition of a mesenchymal phenotype (known as epithelial-mesenchymal transition or EMT). These populations of CTCs may be the most resistant and most prone to metastasis.

  9. Breast cancer stem cell - Wikipedia

    en.wikipedia.org/wiki/Breast_cancer_stem_cell

    The activation of these pathways result in increased proliferation, invasion and migration of BCSCs. As a result, primary breast cancer tumors quickly form metastases in distant sites. Both the epithelial-to-mesenchymal transition (EMT) and the mesenchymal-to-epithelial transition (MET) are key components of driving this metastasis process.