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The relative risks of different types of citrus fruit have not been systematically studied. [1] Affected drugs typically have an auxiliary label saying "Do not take with grapefruit" on the container, and the interaction is elaborated upon in the package insert. [6] People are advised to ask their physician or pharmacist about drug interactions. [6]
That's because the popular citrus fruit shouldn't be combined with certain medications. ... "Many food-drug interactions and potential side effects can be avoided by following certain precautions ...
Grapefruit and grapefruit juice have been found to interact with numerous drugs, in many cases resulting in adverse effects. [4] This happens in two ways: one is that grapefruit can block an enzyme which metabolizes medication, [5] and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to an adverse effect. [5]
Ingestion of naringin and related flavonoids can also affect the intestinal absorption of certain drugs, leading to either an increase or decrease in circulating drug levels. To avoid interference with drug absorption and metabolism, the consumption of citrus (especially grapefruit) and other juices with medications is advised against. [7]
Citrus fruits, such as orange, grapefruit, lemon and lime Other fresh fruits, including kiwifruit, guava and papaya Strawberries, blackberries, raspberries and blueberries
In the past it was called the pomelo, [3] but that term is now mostly used as the common name for Citrus maxima. [4] Grapefruit–drug interactions are common, as the juice contains furanocoumarins that interfere with the metabolism of many drugs. This can prolong and intensify the effects of those drugs, leading to multiple side-effects such ...
Specifically, Silver says, people taking statins or those with chronic diseases who are on immunosuppressant drugs may be advised to avoid citrus, especially grapefruit.
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