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In dogs, the minimum lethal dose of THC is over 3000 mg/kg. [20] According to The Merck Index , [ 21 ] the LD 50 of THC (the dose which causes the death of 50% of individuals) is 1270 mg/kg for male rats and 730 mg/kg for female rats from oral consumption in sesame oil, and 42 mg/kg for rats from inhalation.
A review in the Journal of the American Medical Association stated "Zimmer and Morgan provide an extraordinarily well-researched and passionately argued book on the biomedical and sociological issues raised in today's debate about marijuana. In their desire to 'set the record straight', however, they sometimes sacrifice even-handedness for impact."
Over time, the marijuana gateway hypothesis has been studied more and more. In one published study, the use of marijuana was shown not a reliable gateway cause of illicit drug use. [67] However, social factors and environment influence drug use and abuse, making the gateway effects of cannabis different for those in differing social circumstances.
Here’s where science currently stands on the use of marijuana for pain, sleep, anxiety, muscle spasms and other ailments — the results may surprise you. How marijuana impacts pain, sleep ...
Age. The risk of most causes of joint pain increases with age. This may be due to increased wear and stress on joints over time and a higher likelihood of other underlying medical conditions ...
Marijuana doesn't get the best rap when it comes to mental health. Past research has shown it causes short-term paranoia. New study finds marijuana doesn't cause clinical anxiety or depression
A 2011 review considered cannabis to be generally safe, [33] and it appears safer than opioids in palliative care. [34] A 2022 review concluded the pain relief experienced after using medical cannabis is due to the placebo effect, especially given widespread media attention that sets the expectation for pain relief. [35]
One 2021 study found that ibuprofen tends to be more effective in men than women, while another study discovered that prednisone may cause more uncomfortable side effects in women.