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Pepsin is expressed as a zymogen called pepsinogen, whose primary structure has an additional 44 amino acids compared to the active enzyme. In the stomach, gastric chief cells release pepsinogen. This zymogen is activated by hydrochloric acid (HCl), which is released from parietal cells in the stomach lining.
n/a Ensembl ENSG00000229859 n/a UniProt P0DJD8 n/a RefSeq (mRNA) NM_001079807 n/a RefSeq (protein) NP_001073275 n/a Location (UCSC) Chr 11: 61.2 – 61.21 Mb n/a PubMed search n/a Wikidata View/Edit Human Pepsinogen 3, group I (pepsinogen A) is a protein that in humans is encoded by the PGA3 gene. Function This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the ...
VIP is produced in many tissues of vertebrates including the gut, pancreas, cortex, and suprachiasmatic nuclei of the hypothalamus in the brain. [6] [7] [8] VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gallbladder.
The following are enzymes produced by the stomach and their respective function: Pepsin is the main gastric enzyme. It is produced in the stomach by gastric chief cells in its inactive form pepsinogen, which is a zymogen. Pepsinogen is then activated by the stomach acid into its active form, pepsin.
The gastrointestinal hormones (or gut hormones) constitute a group of hormones secreted by enteroendocrine cells in the stomach, ... pepsinogen, intrinsic factor, and ...
Mucous neck cells produce mucus, parietal cells secrete hydrochloric acid and intrinsic factor, chief cells secrete pepsinogen and gastric lipase. [4] The other type of gastric gland is the pyloric gland which is an endocrine gland that secretes the hormone gastrin produced by its G cells.
Progastricsin also known as pepsinogen C or pepsinogen II is a pepsinogen ... The encoded protein is a digestive enzyme that is produced in the stomach and ...
The gastric chief cell (also known as a zymogenic cell or peptic cell) is a cell in the stomach that releases pepsinogen [1] and chymosin. Pepsinogen is activated into the digestive enzyme pepsin when it comes in contact with hydrochloric acid produced by gastric parietal cells. [2]