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A key member of the Wnt signaling pathway, β-catenin, was thought to be induced by chronic cocaine administration (which had been true in the nucleus accumbens) but acute cocaine reduced expression in the caudate putamen whereas chronic cocaine injections decreased expression even in the NAc in D1 receptor mutants. This pathway influences ...
The effect of these structural changes on behavior is uncertain and studies have produced conflicting results. Two studies [ 18 ] [ 19 ] have shown that an increase in dendritic spine density due to cocaine exposure facilitates behavioral sensitization , while two other studies [ 20 ] [ 21 ] produce contradicting evidence.
Cocaine is a relatively "balanced" inhibitor, although facilitation of dopaminergic neurotransmission is what has been linked to the reinforcing and addictive effects. In addition, cocaine has some serious limitations in terms of its cardiotoxicity [188] due to its local anesthetic activity. Thousands of cocaine users are admitted to emergency ...
The effects of cocaine are similar to those of amphetamines, though cocaine tends to have a shorter duration of effect. In high doses or with prolonged use, cocaine can result in a number of negative effects, including irritability, anxiety, exhaustion, total insomnia, and even psychotic symptomatology.
Most cocaine is grown and processed in South America, particularly in Colombia, Bolivia, Peru, and smuggled into the United States and Europe, the United States being the world's largest consumer of cocaine, [164] where it is sold at huge markups; usually in the US at $80–120 for 1 gram, and $250–300 for 3.5 grams ( 1 / 8 of an ounce ...
Authorities seized 126 packages containing 5.6 tons of suspected cocaine, marking the largest drug seizure of the current administration. The navy said 15 suspects were arrested and over 1,000 ...
Cocaine- and amphetamine-regulated transcript, also known as CART, is a neuropeptide protein that in humans is encoded by the CARTPT gene. [ 1 ] [ 2 ] CART appears to have roles in reward, feeding, and stress, [ 3 ] and it has the functional properties of an endogenous psychostimulant .
TikTokers, news outlets and Twitter feeds are buzzing over ‘cocaine sharks,’ with most out-of-staters dubbing it “another reason not to go to Florida.” 'Cocaine sharks' probably aren't as ...