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Use: For the initial treatment and recurrent episodes of mucosal and cutaneous herpes simplex (HSV-1 and HSV-2). Usual Adult Dose for Herpes Simplex - Mucocutaneous/Immunocompromised Host. Concomitant HIV infection: Treatment of First Episode of Genital Herpes: 400 mg orally 3 times a day for 5 to 10 days (guideline recommendation)
As an example, in a randomized trial of 72 children (one to six years of age) with herpes gingivostomatitis who were treated with one week of oral acyclovir (15 mg/kg up to a dose of 200 mg five times daily) or placebo within three days of illness onset, those who received acyclovir had earlier disappearance of fever (1 versus 3 days), shorter ...
Mucocutaneous Herpes Simplex Virus Infection. Treatment in immunocompromised patients. IV: 5 mg/kg q8hr for 7 days; dosing up to 14 days reported. PO (off-label): 400 mg q4hr while...
Acyclovir can be administered orally to pregnant women with first-episode genital herpes or recurrent herpes and should be administered IV to pregnant women with severe HSV (see Genital Herpes, Hepatitis).
Acyclovir is FDA-approved to treat genital herpes and HSV encephalitis. Non-FDA-approved indications are mucocutaneous HSV, herpes zoster (shingles), and varicella zoster (chickenpox). Acyclovir is the first-line treatment for HSV encephalitis.
The usual dose is 20 mg per kilogram (kg) of body weight, up to 800 mg, four times a day for five days. Children up to 2 years of age—Use and dose must be determined by the doctor. For treatment of shingles: Adults and children 12 years of age and older—800 mg five times a day for seven to ten days.
For the treatment of first episode genital herpes, the dose of oral acyclovir is 200 mg orally five times per day, or 400 mg orally three times per day (Table 64.1). Neither higher doses of oral acyclovir nor the addition of topical acyclovir provide added benefit (Wald et al., 1994).