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Allele frequency. Allele frequency, or gene frequency, is the relative frequency of an allele (variant of a gene) at a particular locus in a population, expressed as a fraction or percentage. [1] Specifically, it is the fraction of all chromosomes in the population that carry that allele over the total population or sample size.
1. Introduce the reference of a SNP of interest, as an example: rs429358, in a database (dbSNP or other). 2. Find MAF/MinorAlleleCount link. MAF/MinorAlleleCount: C=0.1506/754 (1000 Genomes, where number of genomes sampled = N = 2504); [4] where C is the minor allele for that particular locus; 0.1506 is the frequency of the C allele (MAF), i.e. 15% within the 1000 Genomes database; and 754 is ...
Genotype frequency in a population is the number of individuals with a given genotype divided by the total number of individuals in the population. [2] In population genetics, the genotype frequency is the frequency or proportion (i.e., 0 < f < 1) of genotypes in a population. Although allele and genotype frequencies are related, it is ...
Frequency-dependent selection is an evolutionary process by which the fitness of a phenotype or genotype depends on the phenotype or genotype composition of a given population. In positive frequency-dependent selection, the fitness of a phenotype or genotype increases as it becomes more common. In negative frequency-dependent selection, the ...
Category. v. t. e. Darwin's finches. Evolutionary biology is the subfield of biology that studies the evolutionary processes (natural selection, common descent, speciation) that produced the diversity of life on Earth. It is also defined as the study of the history of life forms on Earth.
In population genetics, linkage disequilibrium (LD) is a measure of non-random association between segments of DNA (alleles) at different positions on the chromosome (loci) in a given population based on a comparison between the frequency at which two alleles are detected together at the same loci versus the frequencies at which each allele is ...
The General Selection Model applied to a single gene with two alleles (let's call them A1 and A2) is encapsulated by the equation: where: is the frequency of allele A1. is the frequency of allele A2. is the rate of evolutionary change of the frequency of allele A2. are the relative fitnesses of homozygous A1, heterozygous (A1A2), and homozygous ...
Genetic distance. Genetic distance is a measure of the genetic divergence between species or between populations within a species, whether the distance measures time from common ancestor or degree of differentiation. [ 2 ] Populations with many similar alleles have small genetic distances.