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About 90% of cases of herpes encephalitis are caused by herpes simplex virus-1 (HSV-1), the same virus that causes cold sores. According to a 2006 estimate, 57% of American adults were infected with HSV-1, [3] which is spread through droplets, casual contact and sometimes sexual contact, though most infected people never have cold sores.
Acute necrotizing encephalopathy (ANE) or sometimes necrotizing encephalitis or infection-induced acute encephalopathy (IIAE) is a rare type of brain disease (encephalopathy) that occurs following a viral infection. [4] Most commonly, it develops secondary to infection with influenza A, influenza B, and the human herpes virus 6. ANE can be ...
Following the infection of a cell, a cascade of herpes virus proteins, called immediate-early, early, and late, is produced. Research using flow cytometry on another member of the herpes virus family, Kaposi's sarcoma-associated herpesvirus, indicates the possibility of an additional lytic stage, delayed-late. [41]
Viral encephalitis can occur either as a direct effect of an acute infection, or as one of the sequelae of a latent infection. The majority of viral cases of encephalitis have an unknown cause; however, the most common identifiable cause of viral encephalitis is from herpes simplex infection. [12]
Herpes meningitis is typically self-limiting over 2 weeks without treatment. However, empirical use of antiviral medications such as acyclovir are considered in cases of suspected HSV meningitis to prevent progression to the more rapid and fatal HSV meningoencephalitis. [7] HSV-2 is the most common herpes virus that causes meningitis. [3]
If treated, most individuals recover from viral encephalitis without long-term problems related to the illness. Mortality rates vary for those who do not receive treatment, for example being about 70% for herpes encephalitis [13] but low for the La Crosse virus. Individuals who remain symptomatic after initial infection may have difficulty ...
The viral organisms which cause meningoencephalitis include: Tick-borne encephalitis; West Nile virus; Measles; Epstein–Barr virus; Varicella-zoster virus; Enterovirus; Herpes simplex virus type 1; Herpes simplex virus type 2; Rabies virus; Adenovirus. Meningoencephalitis is almost solely seen in heavily immunocompromised patients. [11] Mumps
Limbic encephalitis is associated with an autoimmune reaction. [1] In non-paraneoplastic limbic encephalitis, this is typically due to infection (commonly herpes simplex virus) or as a systemic autoimmune disorder. [13] Limbic encephalitis associated with cancer or tumors is called paraneoplastic limbic encephalitis. [citation needed]