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Taurine is synthesized naturally in the human liver from methionine and cysteine. [5] Taurine is commonly sold as a dietary supplement, but there is no good clinical evidence that taurine supplements provide any benefit to human health. [6] Taurine is used as a food additive for cats (who require it as an essential nutrient), dogs, and poultry. [7]
Diverse bile acids are synthesized in the liver. [1] Bile acids are conjugated with taurine or glycine residues to give anions called bile salts. [2] [3] [4] Primary bile acids are those synthesized by the liver. Secondary bile acids result from bacterial actions in the colon.
Bile acids are naturally synthesized from cholesterol in the liver and are conjugated with specific amino-acids, specifically taurine. Bear bile contains several bile acids including taurochenodeoxycholic acid, ursodeoxycholic acid, and chenodeoxycholic acid. [2]
Enterohepatic circulation of drugs. Enterohepatic circulation is the circulation of biliary acids, bilirubin, drugs or other substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte and transport back to the liver.
In humans, primary bile acids are synthesized from cholesterol in the liver to form either cholic acid (CA) or chenodeoxycholic acid [clarification needed] (CDCA). [7] These primary bile acids are then conjugated to the amino acids glycine or taurine and stored in the gallbladder. [7]
Primary bile acids are synthesized by hepatocytes in the liver [27] and get conjugated with Taurine or glycine before they are stored in the gall bladder for stimulated secretion. [28] Upon the presence of fats and proteins in the duodenum from the diet, [ 29 ] these primary bile acids get secreted into the intestine where they are converted ...
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