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  2. Gene therapy for blood diseases - Wikipedia

    en.wikipedia.org/wiki/Gene_therapy_for_blood...

    Patients in the U.S. suffering from sickle cell disease can now receive targeted gene therapies using hematopoietic stem cells. [7] Hematopoietic stem cells are stem cells which differentiate and give rise to red blood cells, white blood cells and platelets. [8] These therapies involve removing hematopoietic stem cells from the patient and ...

  3. Stem-cell therapy - Wikipedia

    en.wikipedia.org/wiki/Stem-cell_therapy

    Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.

  4. Hematopoietic stem cell - Wikipedia

    en.wikipedia.org/wiki/Hematopoietic_stem_cell

    Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. [ 16 ] [ 17 ] [ 13 ] It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an ...

  5. Haematopoietic system - Wikipedia

    en.wikipedia.org/wiki/Haematopoietic_system

    Haematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent haematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. [ 10 ] [ 11 ] [ 12 ] It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an ...

  6. Bone marrow failure - Wikipedia

    en.wikipedia.org/wiki/Bone_marrow_failure

    For those with severe bone marrow failure, the cumulative incidence of resulting stem cell transplantation or death was greater than 70% by individuals 60 years of age. [13] The incidence of bone marrow failure is triphasic: one peak at two to five years during childhood (due to inherited causes), and two peaks in adulthood, between 20 and 25 ...

  7. Hematopoietic stem cell transplantation - Wikipedia

    en.wikipedia.org/wiki/Hematopoietic_stem_cell...

    Stem-cell transplantation was pioneered using bone marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognized with a Nobel Prize in Physiology or Medicine. Thomas' work showed that bone-marrow cells infused intravenously could ...

  8. List of conditions treated with hematopoietic stem cell ...

    en.wikipedia.org/wiki/List_of_conditions_treated...

    Mucolipidosis II (I-cell disease) Fucosidosis; Aspartylglucosaminuria; Alpha-mannosidosis; Other Wolman disease (acid lipase deficiency) Immunodeficiencies. T-cell deficiencies Ataxia-telangiectasia; DiGeorge syndrome; Combined T- and B-cell deficiencies Severe combined immunodeficiency (SCID), all types; Well-defined syndromes Wiskott ...

  9. Myelodysplastic syndrome - Wikipedia

    en.wikipedia.org/wiki/Myelodysplastic_syndrome

    Treatments may include supportive care, drug therapy, and hematopoietic stem cell transplantation. [3] Supportive care may include blood transfusions, medications to increase the making of red blood cells, and antibiotics. [3] Drug therapy may include the medications lenalidomide, antithymocyte globulin, and azacitidine. [3]

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