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Marble burying is an animal model used in scientific research to depict anxiety or obsessive–compulsive disorder (OCD) behavior. It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding. [1]
Rodents have been employed in biomedical experimentation from the 1650s. [1] Rodent studies up to the early 19th century were mainly physiological or toxicological.The first rodent behavioral study was carried out in 1822, a purely observational study [2], while quantitative rodent behavioral testing began in the late 19th century [1] [2].
The cages are constructed and designed in a specific way to ensure an absolute microparticle free inner environment. This generally includes a cage bottom, a cage top (with a food hopper and water bottle holder incorporated) and a filter lid. It is also designed to allow maximum comfort of the animal and to provide a secure, chew proof environment.
The Irwin screen was as of 2010 in the pharmaceutical industry almost exclusively used with lab mice, whereas the FOB, or some modification thereof, was used with lab rats and other nonrodent species, such as rabbits, dogs, guinea pigs and nonhuman primates.
Preliminary screening for locomotor effects is needed to determine a false positive results. [ 2 ] Due to the flaws in animal modeling the LDB is best done in a battery of anxiety modeling tests with high predictive validity to determine the potential therapeutic value of a novel agent .
The Liverpool Care Pathway for the Dying Patient (LCP) was a care pathway in the United Kingdom (excluding Wales) covering palliative care options for patients in the final days or hours of life. It was developed to help doctors and nurses provide quality end-of-life care , to transfer quality end-of-life care from the hospice to hospital setting.
The time it takes until it remains immobile is measured. Each animal is tested only once and out of view from the other animals. Within the study there should be two sets of rats, one group which is the control which has been injected with saline and the group being tested which has been injected with the antidepressant-like agents. [5]
Laboratory rats or lab rats are strains of the rat subspecies Rattus norvegicus domestica (Domestic Norwegian rat) which are bred and kept for scientific research. While less commonly used for research than laboratory mice , rats have served as an important animal model for research in psychology and biomedical science , [ 1 ] and "lab rat" is ...
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