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Oclacitinib. Oclacitinib, sold under the brand name Apoquel among others, is a veterinary medication used in the control of atopic dermatitis and pruritus from allergic dermatitis in dogs at least 12 months of age. [1][4] Chemically, it is a synthetic cyclohexylamino pyrrolopyrimidine janus kinase inhibitor that is relatively selective for JAK1 ...
The pharmacokinetics of cetirizine have been found to increase linearly with dose across a range of 5 to 60 mg. [3] Its C max following a single dose has been found to be 257 ng/mL for 10 mg and 580 ng/mL for 20 mg. [2] Food has no effect on the bioavailability of cetirizine but has been found to delay the T max by 1.7 hours (i.e., to ...
Cetirizine/pseudoephedrine (Zyrtec-D) is an antihistamine and decongestant formulation. It is a fixed-dose combination drug containing 5 mg cetirizine hydrochloride and 120 mg pseudoephedrine hydrochloride for symptoms related to seasonal allergic rhinitis. [1][2][3] Cetirizine/pseudoephedrine gained approval from the U.S. Food and Drug ...
After intravenous administration, LD50 (lethal dose for 50% of animals) values were 33 and 45–75 mg/kg in mice and rats, respectively. No signs of toxicity were observed in any organ after bilastine massive overdosing, either orally (in mice, rats and dogs), or intravenously (in rats and dogs) during 4 weeks.
Most allergies occur in dogs over 6 months old. A dog that is repeatedly exposed to a particular allergen becomes sensitized to it, and the immune system overreacts to a subsequent exposure, most commonly manifesting in the form of skin irritation. [1] Some of the signs are redness, itching, hair loss, and recurring skin infections from the ...
Dogs receiving 10 times the labeled dosage rate of enrofloxacin for at least 14 days developed only vomiting and anorexia. Death did occur in some dogs when fed 25 times the labeled rate for 11 days, however. Oral LD 50: greater than 5000 mg/kg; Dermal LD 50: greater than 2000 mg/kg; Inhalation LD 50: greater than 3547 mg/m3 (4-hour exposure)
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