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Scientists Roger Y. Tsien, Osamu Shimomura, and Martin Chalfie were awarded the 2008 Nobel Prize in Chemistry on 10 October 2008 for their discovery and development of the green fluorescent protein. Most commercially available genes for GFP and similar fluorescent proteins are around 730 base-pairs long. The natural protein has 238 amino acids.
Martin Lee Chalfie (born January 15, 1947) is an American scientist. He is University Professor at Columbia University. [3] He shared the 2008 Nobel Prize in Chemistry along with Osamu Shimomura and Roger Y. Tsien "for the discovery and development of the green fluorescent protein, GFP". [4] He holds a PhD in neurobiology from Harvard University.
Roger Yonchien Tsien (pronounced / tʃ ɛ n /, "CHEN"; February 1, 1952 – August 24, 2016) was an American biochemist.He was a professor of chemistry and biochemistry at the University of California, San Diego [7] and was awarded the Nobel Prize in Chemistry in 2008 for his discovery and development of the green fluorescent protein, in collaboration with organic chemist Osamu Shimomura and ...
Douglas Prasher. Douglas C. Prasher (born August 1951) is an American molecular biologist. He is known for his work to clone and sequence the genes for the photoprotein aequorin [1] and green fluorescent protein (GFP) [2] and for his proposal to use GFP as a tracer molecule. [3]
Doctoral advisor. Yoshimasa Hirata. Osamu Shimomura (下村 脩, Shimomura Osamu, August 27, 1928 – October 19, 2018[ 1 ]) was a Japanese organic chemist and marine biologist, and professor emeritus at Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts and Boston University School of Medicine. He was awarded the Nobel Prize in ...
Tulle Inger Hazelrigg is an American biologist who is Professor of Cell Biology at Columbia University. Her research considers the propagation and differentiation of germ cells. Hazelrigg was the first to attach green fluorescent protein to other proteins, which changed the way biological research could be conducted.
pGLO. The pGLO plasmid is an engineered plasmid used in biotechnology as a vector for creating genetically modified organisms. The plasmid contains several reporter genes, most notably the green fluorescent protein (GFP) and the ampicillin resistance gene. GFP was isolated from the jelly fish Aequorea victoria.
During this time, Lippincott-Schwartz began developing techniques to use green fluorescent protein (GFP) to visualize cellular trafficking pathways in living cells. [2] [15] She refined the technique of fluorescence recovery after photobleaching (FRAP) to use in studying the dynamics of membrane proteins. In this method, GFP-tagged membrane ...