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Biguanide (/ b aɪ ˈ ɡ w ɒ n aɪ d /) is the organic compound with the formula HN(C(NH)NH 2) 2. It is a colorless solid that dissolves in water to give a highly basic solution. It is a colorless solid that dissolves in water to give a highly basic solution.
Biguanides reduce hepatic glucose output and increase uptake of glucose by the periphery, including skeletal muscle. Although it must be used with caution in patients with impaired liver or kidney function, Metformin, a biguanide, has become the most commonly used agent for type 2 diabetes in children and teenagers. Among common diabetic drugs ...
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, [ 4 ] it is spelled polihexanide ( INN ) and sold under various brand names. [ 5 ]
A retrospective analysis of wound cleanser clinical efficacy and cost-effectiveness focused on polyhexamethylene biguanide solution, Ringer's solution or saline in 112 venous leg ulcer patients. [31] The study group received the polyhexamethylene biguanide solution (n=59) and the control group received either Ringer's solution or saline (n=53).
Structure of chlorhexidine, a bisbiguanide antiseptic.. Bisbiguanides are a class of chemically related compounds known for their bactericidal properties. Generally considered to be of the generic formula: R 1 R 2 N.C(:NR 6)NH.C(:NH)NH.CH 2 X--(CH 2) 3 NH.C(:NH)NH.C(:NR 7)NR 3 R 4 V. [1] These compounds include the antiseptics chlorhexidine and alexidine.
At some point before surgery a health care provider conducts a preoperative assessment to verify that a person is fit and ready for the surgery. [ 1 ] [ 2 ] For surgeries in which a person receives either general or local anesthesia, this assessment may be done either by a doctor or a nurse trained to do the assessment. [ 2 ]
SGLT2 inhibitors may need to be discontinued before surgery, and only recommended when someone is not unwell, is adequately hydrated and able to consume a regular diet. [14] Symptoms of ketoacidosis include nausea, vomiting, abdominal pain, tiredness, and trouble breathing. [ 15 ]
Phenformin is an antidiabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis, which was fatal in 50% of cases. Phenformin was developed in 1957 by Ungar, Freedman and Seymour Shapiro, working for the U.S. Vitamin Corporation ...