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The cause of acute liver injury from cetirizine is not known. It is metabolized by the liver and a toxic metabolite may account for idiosyncratic injury. Outcome and Management. Acute liver injury from cetirizine and levocetirizine is rare and usually self-limited.
There are several medications and supplements that can cause liver damage. Certain antibiotics, anti-seizure medications, and cancer treatments are prescription-only examples. But OTC products like Tylenol (acetaminophen), bodybuilding supplements, and green tea extracts can also cause liver injury.
Serious side effects of Zyrtec. Along with its needed effects, cetirizine (the active ingredient contained in Zyrtec) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Drug-induced liver damage is a frequently encountered clinical table caused by many drugs. Cetirizine is a widely preferred and prescribed antihistaminic agent for allergic disorders due to its non-sedative properties.
These common side effects include sedation, impaired motor function, dizziness, dry mouth and throat, blurred vision, urinary retention and constipation. Antihistamines can worsen urinary retention and narrow angle glaucoma. The antihistamines rarely cause liver injury.
In view of the literature, we present four cases of hepatotoxicity due to cetirizine use. We conclude that in patients with high levels of liver enzymes of unknown origin, cetirizine as well as other hepatotoxic drugs should be reconsidered.
If you have liver or kidney disease, ask your doctor about taking cetirizine. If your doctor feels it’s safe for you to take, they may recommend taking less than the typical dosage. Interactions...
Numerous drugs have been reported to cause liver injury, but only one case of LCZ-induced liver injury, which lacked histologic confirmation, has been described. Furthermore, unlike the previous case of LCZ-induced liver injury, our patient showed >20-fold elevation of serum AST and ALT levels.
Cetirizine was therefore considered to the likely cause for the increased values of the liver tests (AST, ALT, ALP, GGT and total bilirubin). ... Focus on the cetirizine...
Cetirizine was therefore considered to the likely cause for the increased values of the liver tests (AST, ALT, ALP, GGT and total bilirubin). The authors concluded that in patients with high levels of liver enzymes of unknown origin, cetirizine, as well as other hepatotoxic drugs, should be reconsidered.