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The dialysis process does not efficiently remove excess aluminium from the body, so it may build up over time. [2] Aluminium is a potentially toxic metal, and aluminium poisoning may lead to mainly three disorders: aluminium-induced bone disease, microcytic anemia and neurological dysfunction (encephalopathy).
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Deferoxamine (DFOA), also known as desferrioxamine and sold under the brand name Desferal, is a medication that binds iron and aluminium. [1] It is specifically used in iron overdose, hemochromatosis either due to multiple blood transfusions or an underlying genetic condition, and aluminium toxicity in people on dialysis.
Schematic of semipermeable membrane during hemodialysis, where blood is red, dialysing fluid is blue, and the membrane is yellow. Kidney dialysis (from Greek διάλυσις, dialysis, 'dissolution'; from διά, dia, 'through', and λύσις, lysis, 'loosening or splitting') is the process of removing excess water, solutes, and toxins from the blood in people whose kidneys can no longer ...
Hemodialysis, also spelled haemodialysis, or simply dialysis, is a process of filtering the blood of a person whose kidneys are not working normally. This type of dialysis achieves the extracorporeal removal of waste products such as creatinine and urea and free water from the blood when the kidneys are in a state of kidney failure.
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Aluminium citrate takes up about 8% of aluminium in blood [3] due to the ability of Al 3+ ions to replace Ca 2+ from calcium citrate and is known to cause chronic renal failure because it causes an increase of phosphorus in the kidneys. [4] It has been suspected to cause Alzheimer's disease but more evidence is needed. [5]
Christopher Exley is an English chemist known for his research on the health effects of aluminium exposure. He was Professor of Bioinorganic Chemistry and group leader of the Bioinorganic Chemistry Laboratory at Keele University.