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Two other uses for spinosad are for pets and humans. Spinosad has been used in oral preparations (as Comfortis) to treat C. felis, the cat flea, in canines and felines; the optimal dose set for canines is reported to be 30 mg/kg. [5] Spinosad is sold under the brand names, Comfortis, Trifexis, and Natroba.
Dosage of atropine is different among different age-groups. Children and infants have a maximum dosage of 0.05 mg/kg. When adults are severely intoxicated the dose can go up to 4 mg. In mild cases 1 or 2 mg will be required. In total, during the first 24 hours 20 or 30 mg might be required. [11]
Up to and including 50 mg/kg From 50 to 500 mg/kg From 500 to 5000 mg/kg Greater than 5000 mg/kg Inhalation LC50 Up to and including 0.2 mg/L From 0.2 to 2 mg/L From 2. to 20 mg/L Greater than 20 mg/L Dermal LD50 Up to and including 200 mg/kg From 200 to 2000 mg/kg From 2000 to 20,000 mg/kg Greater than 20,000 mg/kg Eye Effects
The system is based on LD50 determination in rats, thus an oral solid agent with an LD50 at 5 mg or less/kg bodyweight is Class Ia, at 5–50 mg/kg is Class Ib, LD50 at 50–2000 mg/kg is Class II, and at LD50 at the concentration more than 2000 mg/kg is classified as Class III. Values may differ for liquid oral agents and dermal agents. [1]
For example, the EPA set an acute RfD for children of 0.0015 mg/kg/day for the organochlorine insecticide endosulfan, based on neurological effects observed in test animals. The EPA then looked at dietary exposure to endosulfan, and found that for the most exposed 0.1 % of children age 1–6, their daily consumption of the endosulfan exceeded ...
CNN asked convicted felons about their struggles, their hopes and how they feel about President-elect Donald Trump, who will return to the White House after being convicted of 34 felony charges.
The Oxford University chemical safety data documents an LD50 toxicology test on rats, both male and female, where doses are recorded as 1680 mg and 1575 mg per kg body weight respectively. [3] As such, the overdose limits for humans and animals are quite high, reaching into grams, and the compound is seen as safe for daily use for animals.
Its oral LD 50 for rats is 90 to 250 mg/kg bw, inhalation LC 50 is 0.61 mg/L. Carbosulfan is only slightly absorbed through skin (LD 50 >2000 mg/kg for rabbits). The mechanism of toxicity is based on reversible inhibition of acetylcholinesterase (as for carbamates generally). [ 3 ]