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Lamotrigine, sold under the brand name Lamictal among others, is a medication used to treat epilepsy and stabilize mood in bipolar disorder. [ 5 ] [ 8 ] For epilepsy, this includes focal seizures , tonic-clonic seizures , and seizures in Lennox-Gastaut syndrome . [ 8 ]
While lithium is typically the most effective treatment, possible alternatives to Lithium include Lamotrigine and Second generation Antipsychotics for the treatment of acute bipolar depression or for the management of bipolar patients with normal mood during pregnancy.
Lamotrigine is known to decrease the patient's cortisol response to stress. [ citation needed ] One possible downstream target of several mood stabilizers such as lithium, valproate, and carbamazepine is the arachidonic acid cascade .
Lamotrigine (Lamictal®) Lithium (Eskalith®, Lithobid®) Some studies show that the most effective treatment results from medication have been seen from combinations of mood stabilizers and ...
Among bipolar patients taking anticonvulsants, those on lamotrigine have a better cognitive profile than those on carbamazepine, valproate, topiramate, and zonisamide. [36] Although decreased verbal memory and slowed psychomotor speed are common side effects of lithium use [37] [38] these side effects usually disappear after discontinuation of ...
Lamictal (lamotrigine) – an anticonvulsant used as a mood stabilizer; Latuda – an atypical antipsychotic; Lexapro (escitalopram) – an antidepressant of the SSRI class; Librium (chlordiazepoxide) – a benzodiazepine used to treat acute alcohol withdrawal; Lithobid, Eskalith – a mood stabilizer
Lithium and the anticonvulsants carbamazepine, lamotrigine, and valproic acid are classed as mood stabilizers due to their effect on the mood states in bipolar disorder. [117] Lithium has the best overall evidence and is considered an effective treatment for acute manic episodes, preventing relapses, and bipolar depression.
In 1948, lithium was first used as a psychiatric medicine. One of the most important discoveries was chlorpromazine , an antipsychotic that was first given to a patient in 1952. In the same decade, Julius Axelrod carried out research into the interaction of neurotransmitters, which provided a foundation for the development of further drugs. [ 9 ]
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