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Magnetic particle imaging (MPI) is an emerging non-invasive tomographic technique that directly detects superparamagnetic nanoparticle tracers. The technology has potential applications in diagnostic imaging and material science .
To increase spatial resolution, bias voltage between the tip and the sample can be applied which causes thin film atoms to migrate towards the tip apex making it sharper. Even with thin film deposition, the tip will still carry a magnetic stray field that can perturb the sample. [5] [6] Nonmagnetic tip with a cluster of magnetic material.
Among techniques that rely on the latter are those that improve the resolution only modestly (up to about a factor of two) beyond the diffraction-limit, such as confocal microscopy with closed pinhole or aided by computational methods such as deconvolution [5] or detector-based pixel reassignment (e.g. re-scan microscopy, [6] pixel reassignment ...
Super-resolution imaging (SR) is a class of techniques that improve the resolution of an imaging system. In optical SR the diffraction limit of systems is transcended, while in geometrical SR the resolution of digital imaging sensors is enhanced.
Tip-enhanced Raman spectroscopy (TERS) is a variant of surface-enhanced Raman spectroscopy (SERS) [1] that combines scanning probe microscopy with Raman spectroscopy. High spatial resolution chemical imaging is possible via TERS, [2] with routine demonstrations of nanometer spatial resolution under ambient laboratory conditions, [3] or better [4] at ultralow temperatures and high pressure.
Small-angle X-ray scattering (SAXS) is a small-angle scattering technique by which nanoscale density differences in a sample can be quantified. This means that it can determine nanoparticle size distributions, resolve the size and shape of (monodisperse) macromolecules, determine pore sizes and characteristic distances of partially ordered materials. [1]
This has been written for one spatial dimension, but most imaging systems are two dimensional, with the source, detected image, and point spread function all having two indices. So a two dimensional detected image is a convolution of the underlying image with a two dimensional point spread function P ( Δ x , Δ y ) {\displaystyle P(\Delta x ...
Magnetic resonance spectroscopic imaging (MRSI) combines both spectroscopic and imaging methods to produce spatially localized spectra from within the sample or patient. The spatial resolution is much lower (limited by the available SNR ), but the spectra in each voxel contains information about many metabolites.