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BK virus is an abbreviation of the name of the first patient, from whom the virus was isolated in 1971. This patient - a male - was then 39 years old, who had developed constriction of the ureter after a renal transplant. [2]
Diseases caused by human polyomavirus infections are most common among immunocompromised people; disease associations include BK virus with nephropathy in renal transplant and non-renal solid organ transplant patients, [8] [9] JC virus with progressive multifocal leukoencephalopathy, [10] and Merkel cell virus (MCV) with Merkel cell cancer. [11]
In renal transplant recipients, such cells may be found in up to 40 percent of cases. [1] Decoy cells are clinically relevant since they may be used as a prognostic marker for clinical conditions such as polyomavirus BK-induced nephropathy in renal transplant recipients, and haemorrhagic cystitis in haematopoietic stem cell transplant ...
[79] [81] BK virus is now being increasingly recognised as a transplant risk factor which may lead to kidney disease or transplant failure if untreated. [82] Infection is the cause of death in about one third of people with renal transplants, and pneumonias account for 50% of the patient deaths from infection. [80]
Akkina is one of the researchers involved with a phase 3 trial in organ transplant patients that uses stem cells taken from the organ donor in an attempt to wean the recipients off of these drugs ...
Radiation-induced hemorrhagic cystitis develops in similar or smaller patient numbers when compared to cyclophosphamide-induced cases. [3] Adenovirus (particularly serotypes 11 and 21 of subgroup B) is the most common cause of acute viral hemorrhagic cystitis in children, though it can result from BK virus as well. A chemical hemorrhagic ...
HPyV9 was first discovered in 2011 by generic PCR used to screen clinical samples from patients who were immunocompromised for various reasons. The virus was identified in a sample from a kidney transplant recipient and sequenced to reveal a genome of typical polyomavirus structure, particularly closely related to the African green monkey lymphotropic polyomavirus (LPV).
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