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Suture granuloma, with multinucleated giant cells surrounding (grey) suture material. Foreign bodies indicate a foreign body granuloma. Specific forms of multinucleated giant cells include the Touton giant cell, which contains a ring of nuclei surrounding a central homogeneous cytoplasm, with foamy cytoplasm surrounding the nuclei.
Sutures are generally ammonitic, characterized by complex saddle and lobe patterns. However, in some derived forms, the suture pattern becomes simplified, appearing ceratitic or even goniatitic. The Ammonitina are derived from the Phylloceratina, another ammonitid suborder which has its origin in the Ceratitida of the Triassic .
Granuloma annulare (GA) is a rare, [1] sometimes chronic skin condition which presents as reddish bumps on the skin arranged in a circle or ring. [2] It can initially occur at any age, though two-thirds of patients are under 30 years old, and it is seen most often in children and young adults. Females are two times as likely to have it as males ...
Alfred Blaschko, a private practice dermatologist from Berlin, first described and drew the patterns of the lines of Blaschko in 1901. He obtained his data by studying over 140 patients with various nevoid and acquired skin diseases and transposed the visible patterns the diseases followed onto dolls and statues, then compiled the patterns onto a composite schematic of the human body.
The topology of the septa, especially around the rim, results in the various suture patterns found. [5] The septal curvature in nautiloids and ammonoids also differ in that the septa curves towards the opening in nautiloids, and away from the opening in ammоnoids. [6] Regions of the suture line and variants in suture patterns Ammonite clean cut
Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, [1] [2] is a skin disease characterized by the sudden onset of fever, an elevated white blood cell count, and tender, red, well-demarcated papules and plaques that show dense infiltrates by neutrophil granulocytes on histologic examination.
The sutures of nautiloids are by comparison somewhat simpler, being either straight or slightly curved, whereas later ammonoids showed suture patterns of increasing complexity. One explanation for this increasing extravagancy in suture pattern is that it leads to a higher strength of the shell.
The histological picture involves thinner, weaker attachments of the skin lesion itself to the normal skin – resulting in easier dislodgement. The formation of new blisters upon slight pressure (direct Nikolsky) and shearing of the skin due to rubbing (indirect Nikolsky) is a sign of pemphigus vulgaris, albeit not a 100% reliable diagnosis. [ 8 ]