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  2. High-performance liquid chromatography - Wikipedia

    en.wikipedia.org/wiki/High-performance_liquid...

    HPLC has many applications in both laboratory and clinical science. It is a common technique used in pharmaceutical development, as it is a dependable way to obtain and ensure product purity. [59] While HPLC can produce extremely high quality (pure) products, it is not always the primary method used in the production of bulk drug materials. [60]

  3. Charged aerosol detector - Wikipedia

    en.wikipedia.org/wiki/Charged_Aerosol_Detector

    The charged aerosol detector (CAD) is a detector used in conjunction with high-performance liquid chromatography (HPLC) and ultra high-performance liquid chromatography (UHPLC) to measure the amount of chemicals in a sample by creating charged aerosol particles which are detected using an electrometer.

  4. Evaporative light scattering detector - Wikipedia

    en.wikipedia.org/wiki/Evaporative_light...

    An evaporative light scattering detector (ELSD) is a destructive chromatography detector, used in conjunction with high-performance liquid chromatography (HPLC), [1] ultra high-performance liquid chromatography (UHPLC), [2] purification liquid chromatography such as flash or preparative chromatography (using a splitter), countercurrent or ...

  5. Quadrupole mass analyzer - Wikipedia

    en.wikipedia.org/wiki/Quadrupole_mass_analyzer

    Only ions of a certain mass-to-charge ratio will reach the detector for a given ratio of voltages: other ions have unstable trajectories and will collide with the rods. This permits selection of an ion with a particular m/z or allows the operator to scan for a range of m/z -values by continuously varying the applied voltage. [ 2 ]

  6. Chromatography detector - Wikipedia

    en.wikipedia.org/wiki/Chromatography_detector

    A chromatography detector is a device that detects and quantifies separated compounds as they elute from the chromatographic column.These detectors are integral to various chromatographic techniques, such as gas chromatography, [1] liquid chromatography, and high-performance liquid chromatography, [2] and supercritical fluid chromatography [3] among others.

  7. Differential refractometer - Wikipedia

    en.wikipedia.org/wiki/Differential_refractometer

    A differential refractometer (DRI), or refractive index detector (RI or RID) is a detector that measures the refractive index of an analyte relative to the solvent. They are often used as detectors for high-performance liquid chromatography and size exclusion chromatography. They are considered to be universal detectors because they can detect ...

  8. Dynamic light scattering - Wikipedia

    en.wikipedia.org/wiki/Dynamic_light_scattering

    Dynamic light scattering (DLS) is a technique in physics that can be used to determine the size distribution profile of small particles in suspension or polymers in solution. [1] In the scope of DLS, temporal fluctuations are usually analyzed using the intensity or photon autocorrelation function (also known as photon correlation spectroscopy ...

  9. Analytical light scattering - Wikipedia

    en.wikipedia.org/wiki/Analytical_light_scattering

    A typical ALS instrument consists of an HPLC/FPLC chromatography system coupled in-line with appropriate light scattering and refractive index detectors. The advantage of ALS over conventional steady-state light scattering methods is that it allows separation of molecules / macromolecules on a chromatography column prior to analysis with light ...

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