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Micrograph of a vacuolar interface dermatitis with dermal mucin, as may be seen in lupus. H&E stain. Vacuolar interface dermatitis (VAC, also known as liquefaction degeneration, vacuolar alteration or hydropic degeneration) is a dermatitis with vacuolization at the dermoepidermal junction, with lymphocytic inflammation at the epidermis and ...
Rarely eosinophils [1] Allergic drug reaction Rarely involvement of hair follicles. [1] Frequently eosinophils [1] Lichen sclerosus: Hyperkeratosis, atrophic epidermis, sclerosis of dermis and dermal lymphocytes. [2] Erythema multiforme Lupus erythematosis Typical findings in systemic lupus erythematosus: [3] Fibrinoid necrosis at the ...
Skin biopsy of the affected areas may show an increased number of eosinophils. [2] Other conditions that may appear similar include cellulitis, contact dermatitis, and severe allergic reactions such as anaphylaxis. [2] Treatment is often with a corticosteroids. [2] Steroids applied as a cream is generally recommended over the use of steroids by ...
Typically a superficial and deep perivascular lymphocytic infiltrate. [22] Plasma cells are typically located at the periphery of the lesion, whereas eosinophils are in the center. [22] Kaposi’s sarcoma in patch stage The patch stage typically shows irregular proliferation of jagged vascular channels in the dermis below an integral epidermis.
More than 1,500/mL of blood eosinophilia for more than six months in a row, along with hypereosinophilic disease signs and symptoms. [23] Lack of an underlying cause for hypereosinophilia after a full diagnostic assessment. [23] Organ dysfunction or damage as a result of eosinophils' toxic contents being released locally. [23]
Based on their causes, hypereosinophilias can be sorted into subtypes. However, cases of eosinophilia, which exhibit eosinophil counts between 500 and 1,500/μL, may fit the clinical criteria for, and thus be regarded as falling into, one of these hypereosinophilia categories: the cutoff of 1,500/μL between hypereosinophilia and eosinophilia is somewhat arbitrary.
The exact cause of this condition is not known, but it involves collagen degeneration and a granulomatous response in the layer of the skin called the dermis, often affecting the deeper fat layer and thickening dermal blood vessels. Diagnosis is confirmed through a skin biopsy showing inflammatory cell infiltrate and necrotising vasculitis.
TEN is a type of severe cutaneous adverse reactions (SCARs), together with SJS, a SJS/TEN, and drug reaction with eosinophilia and systemic symptoms. [5] It is called SJS when less than 10% of the skin is involved and an intermediate form with 10 to 30% involvement. [3] Erythema multiforme (EM) is generally considered a separate condition. [6]