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Micrograph of a vacuolar interface dermatitis with dermal mucin, as may be seen in lupus. H&E stain. Vacuolar interface dermatitis (VAC, also known as liquefaction degeneration, vacuolar alteration or hydropic degeneration) is a dermatitis with vacuolization at the dermoepidermal junction, with lymphocytic inflammation at the epidermis and ...
Mild superficial perivascular infiltrate of lymphocytes, histiocytes and occasional neutrophils. There is some exocytosis of inflammatory cells but not as prominent as in nummular dermatitis; Typical findings: [5] Psoriasiform hyperplasia, initially slight, with mild spongiosis; Usually numerous yeast-like organisms in the surface keratin
Causes of vacuolar interface dermatitis ; Main conditions [1] Characteristics Micrograph Photograph Generally/Not otherwise specified Typical findings, called "vacuolar interface dermatitis": [1] Mild inflammatory cell infiltrate along the dermoepidermal junction (black arrow in image) Vacuolization within the basal keratinocytes (white arrow ...
Skin biopsy of the affected areas may show an increased number of eosinophils. [2] Other conditions that may appear similar include cellulitis, contact dermatitis, and severe allergic reactions such as anaphylaxis. [2] Treatment is often with a corticosteroids. [2] Steroids applied as a cream is generally recommended over the use of steroids by ...
The dermis contains two vascular networks that run parallel to the skin surface—one superficial and one deep plexus—which are connected by vertical communicating vessels. [8] [11] The function of blood vessels within the dermis is fourfold: to supply nutrition, to regulate temperature, to modulate inflammation, and to participate in wound ...
Based on their causes, hypereosinophilias can be sorted into subtypes. However, cases of eosinophilia, which exhibit eosinophil counts between 500 and 1,500/μL, may fit the clinical criteria for, and thus be regarded as falling into, one of these hypereosinophilia categories: the cutoff of 1,500/μL between hypereosinophilia and eosinophilia is somewhat arbitrary.
[1] [14] However the term eczema is often used to specifically mean atopic dermatitis (also known as atopic eczema). [15] [7] Terminology might also differ according to countries. In some languages, dermatitis and eczema mean the same thing, while in other languages dermatitis implies an acute condition and eczema a chronic one. [16]
Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, [1] [2] is a skin disease characterized by the sudden onset of fever, an elevated white blood cell count, and tender, red, well-demarcated papules and plaques that show dense infiltrates by neutrophil granulocytes on histologic examination.