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The relationship between the amount of vitamin B 6 consumed and the serum levels of those who consume it varies between individuals. [52] Some people may have high serum concentrations without neuropathy symptoms. [13] [53] [54] It is not known if inhalation of vitamin B 6 while, for example, working with animal feed containing vitamin B 6 is ...
Vitamin B 6 Drug class Pyridoxal 5'-phosphate, the metabolically active form of vitamin B 6 Class identifiers Use Vitamin B 6 deficiency ATC code A11H Biological target enzyme cofactor Clinical data Drugs.com International Drug Names External links MeSH D025101 Legal status In Wikidata Vitamin B 6 is one of the B vitamins, and is an essential nutrient for humans. The term essential nutrient ...
Vitamin B6 is thought to lead to neuropathy due to its cytoskeletal and microtubule toxicity leading to nerve cell loss with prolonged overdosing. [ 2 ] Possible infectious causes of sensory neuronopathy include HIV (in which lymphocyte infiltrates have been observed in the dorsal root ganglion), Human T-lymphotropic virus 1 , Epstein-Barr ...
Vitamin B6 is "important in the function of the body’s metabolism, brain health, hemoglobin production, and immune function," Washington, D.C.-based dietitian Caroline Thomason, R.D., tells USA ...
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Evidence exists linking elevated homocysteine levels with vascular dementia [10] and Alzheimer's disease. [11] [12] [13] There is also evidence that elevated homocysteine levels and low levels of vitamin B6 and B12 are risk factors for mild cognitive impairment and dementia. [14]
In general, lower levels of enzyme activity correlate with more severe symptoms. The decrease in ALP activity leads to an increase in pyridoxal 5’-phosphate (PLP), which is the major form of Vitamin B6, in the blood, although tissue levels of Vitamin B6 may be unremarkable [30] and correlates with disease severity. [31]
Pyridoxine overdose can cause a peripheral sensory neuropathy characterized by poor coordination, numbness, and decreased sensation to touch, temperature, and vibration. [11] Healthy human blood levels of pyridoxine are 2.1–21.7 ng/mL. Normal doses are safe during pregnancy and breastfeeding. [5]
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