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Simply switching the patient from 40 mg of morphine to 10 mg of levorphanol would be dangerous due to dose accumulation, and hence frequency of administration should also be taken into account. There are other concerns about equianalgesic charts. Many charts derive their data from studies conducted on opioid-naive patients.
Latin, "at one's pleasure"; as much as one desires; freely compare pro re nata, "as needed", which by convention includes an aspect of "up to some maximum". Similarly, compare s.o.s., q.l., and q.s. admov. admove admoveatur: apply [or] add add; let there be added ad us. ad usum: according to custom æq. æquales: equal agit. agita
As one of the chief components of the extracellular matrix, it contributes significantly to cell proliferation and migration, and is involved in the progression of many malignant tumors. [ 7 ] [ 8 ] Hyaluronic acid is also a component of the group A streptococcal extracellular capsule , [ 9 ] and is believed to play a role in virulence .
In clinical pharmacology, dose refers to the amount of drug administered to a person, and dosage is a fuller description that includes not only the dose (e.g., "500 mg") but also the frequency and duration of the treatment (e.g., "twice a day for one week").
The AUC (from zero to infinity) represents the total drug exposure across time. AUC is a useful metric when trying to determine whether two formulations of the same dose (for example a capsule and a tablet) result in equal amounts of tissue or plasma exposure. Another use is in the therapeutic drug monitoring of drugs with a narrow therapeutic ...
From or to a drug trade name: This is a redirect from (or to) the trade name of a drug to (or from) the international nonproprietary name (INN).
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In this one-compartment model, the most common model of elimination is first order kinetics, where the elimination of the drug is directly proportional to the drug's concentration in the organism. This is often called linear pharmacokinetics , as the change in concentration over time can be expressed as a linear differential equation d C d t ...
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