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In 2012 and 2013, CRISPR was a runner-up in Science Magazine's Breakthrough of the Year award. In 2015, it was the winner of that award. [ 198 ] CRISPR was named as one of MIT Technology Review ' s 10 breakthrough technologies in 2014 and 2016.
Cas9 (or "CRISPR-associated protein 9") is an enzyme that uses CRISPR sequences as a guide to recognize and open up specific strands of DNA that are complementary to the CRISPR sequence. Cas9 enzymes together with CRISPR sequences form the basis of a technology known as CRISPR-Cas9 that can be used to edit genes within living organisms.
Jennifer Doudna was born February 19, 1964, in Washington, D.C., as the daughter of Dorothy Jane (Williams) and Martin Kirk Doudna. [2] [17] Her father received his PhD in English literature from the University of Michigan, and her mother held a master's degree in education.
CRISPR Therapeutics' development of Casgevy helped validate its gene-editing platform. The company's innovative approach should yield more solid clinical and regulatory wins in the next five years.
On 26 November 2018, The CRISPR Journal published ahead of print an article by He, Ryan Ferrell, Chen Yuanlin, Qin Jinzhou, and Chen Yangran in which the authors justified the ethical use of CRISPR gene editing in humans. [74] As the news of CRISPR babies broke out, the editors reexamined the paper and retracted it on 28 December, announcing:
CRISPR Therapeutics (NASDAQ: CRSP) isn't a stock that's wanting for reasons to invest. ... For one, it grants the bearer all of the upsides associated with the fast-track and breakthrough-therapy ...
The Breakthrough of the Year is an annual award for the most significant development in scientific research made by the AAAS journal Science, an academic journal covering all branches of science. [1] Originating in 1989 as the Molecule of the Year, [2] and inspired by Time 's Person of the Year, it was renamed the Breakthrough of the Year in 1996.
The CRISPR-Cas system was selected by Science as 2015 Breakthrough of the Year. [5] As of 2015 four families of engineered nucleases were used: meganucleases, zinc finger nucleases (ZFNs), transcription activator-like effector-based nucleases (TALEN), and the clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) system.
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