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Terbinafine given for 2 to 4 weeks is at least as effective as griseofulvin given for 6 to 8 weeks for treatment of Trichophyton scalp infections. However, griseofulvin is more effective than terbinafine for treatment of Microsporum scalp infections. [8] [9]
Ketoconazole by mouth is not recommended due to side effects. [27] Oral terbinafine is better tolerated than itraconazole. [28] For superficial white onychomycosis, systemic rather than topical antifungal therapy is advised. [29] Topical agents include ciclopirox nail paint, amorolfine, and efinaconazole.
Terbinafine is an antifungal medication used to treat pityriasis versicolor, fungal nail infections, and ringworm including jock itch and athlete's foot. [ 1 ] [ 2 ] [ 3 ] It is either taken by mouth or applied to the skin as a cream or ointment.
It is a fixed dose combination of terbinafine, an antifungal; and betamethasone acetate, a glucocorticosteroid anti-inflammatory. [ 1 ] [ 2 ] The combination is the first FDA-approved animal drug intended to treat yeast-only otitis externa in dogs. [ 2 ]
Where risks or harms is the reason for withdrawal, this will usually have been prompted by unexpected adverse effects that were not detected during Phase III clinical trials, i.e. they were only made apparent from postmarketing surveillance data collected from the wider community over longer periods of time.
Like the allylamine antifungals (e.g terbinafine), butenafine works by inhibiting the synthesis of ergosterol by binding to and inhibiting squalene epoxidase, an enzyme in the pathway used for creation of the sterols needed in fungal cell membranes. Lacking ergosterol, the cell membranes increase in permeability, allowing their contents to leak ...
[16] [17] The total duration of treatment is therefore generally two weeks, [18] [19] but may be as long as three. [20] In more severe cases or scalp ringworm, systemic treatment with oral medications (such as itraconazole, terbinafine, and ketoconazole) may be given. [21]
Tolnaftate has been found to be generally slightly less effective than azoles when used to treat tinea pedis (athlete's foot). It is, however, useful when dealing with ringworm , especially when passed from pets to humans.
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