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Unlike traditional antidepressants that target the neurotransmitters serotonin and/or norepinephrine, ketamine targets glutamate — the most abundant chemical messenger in the brain, Feifel said.
Ketamine infusions have been a game-changer for many with treatment-resistant depression and other mental health issues. But when Matthew Perry died from “acute effects of ketamine” a year ago ...
Ketamine crystals on a glass plate. K-hole is the feeling of getting a high enough dose of ketamine to experience a state of dissociation.This intense detachment from reality is often a consequence of accidental overconsumption of ketamine; however, some users consciously seek out the k-hole as they find the powerful dissociative effects to be quite pleasurable and enlightening.
Dr. Steven Levine, a board-certified psychiatrist who developed the protocol for the clinical use of ketamine in 2011, previously told Yahoo that ketamine can “enable the brain to heal and ...
Ketamine potentiates the sedative effects of propofol [85] and midazolam. [86] Naltrexone potentiates psychotomimetic effects of a low dose of ketamine, [87] while lamotrigine [38] and nimodipine [39] decrease them. Clonidine reduces the increase of salivation, heart rate, and blood pressure during ketamine anesthesia and decreases the ...
Ketamine-assisted psychotherapy (KAP) is the use of prescribed doses of ketamine as an adjunct to psychotherapy sessions. KAP shows significant potential in treating mental disorders such as treatment-resistant depression (TRD), anxiety, obsessive–compulsive disorders (OCD), post-traumatic stress disorders (PTSD), and other conditions. [1]
Perry died in October 2023 from the "acute effects of ketamine." He was 54. ... "There are times when I have sort of a … negative chemical state in my brain, like depression I guess, or ...
A 2000 landmark study showcased the drug's antidepressant and anti-suicidal effects, and more recent studies have supported ketamine's high rate of success in treating persistent depression.