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1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC, EDAC or EDCI) is a water-soluble carbodiimide usually handled as the hydrochloride. [1] It is typically employed in the 4.0-6.0 pH range. It is generally used as a carboxyl activating agent for the coupling of primary amines to yield amide bonds.
ethyl 3-oxo-4-phenylbutanoate phenylacetone: ethyl-3-(1,3-benzodioxol-5-yl)-2-methyloxirane-2-carboxylate (MDP2P ethyl glycidate) MDMA: Formamide: amphetamine, methamphetamine Formic acid: amphetamine, methamphetamine Lithium aluminum hydride: amphetamine, methamphetamine Lithium metal amphetamine, methamphetamine Magnesium metal (turnings ...
The acid 1 will react with the carbodiimide to produce the key intermediate: the O-acylisourea 2, which can be viewed as a carboxylic ester with an activated leaving group. The O-acylisourea will react with amines to give the desired amide 3 and urea 4 .
nh 3 + 3 c 2 h 5 oh → n(c 2 h 5) 3 + 3 h 2 o The pK a of protonated triethylamine is 10.75, [ 4 ] and it can be used to prepare buffer solutions at that pH. The hydrochloride salt , triethylamine hydrochloride (triethylammonium chloride), is a colorless, odorless, and hygroscopic powder, which decomposes when heated to 261 °C.
PRL-8-53 is a nootropic substituted phenethylamine that has been shown to act as a hypermnesic drug in humans; it was first synthesized by medical chemistry professor Nikolaus Hansl at Creighton University in the 1970s as part of his work on amino ethyl meta benzoic acid esters.
A common way to synthesize an NHS-activated acid is to mix NHS with the desired carboxylic acid and a small amount of an organic base in an anhydrous solvent. A coupling reagent such as dicyclohexylcarbodiimide (DCC) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) is then added to form a highly reactive activated acid intermediate.
N-Methyl-3-piperidyl benzilate (JB-336, BZ) Piperidine is also commonly used in chemical degradation reactions, such as the sequencing of DNA in the cleavage of particular modified nucleotides . Piperidine is also commonly used as a base for the deprotection of Fmoc - amino acids used in solid-phase peptide synthesis .
N,N-Dimethylethylamine (DMEA), sometimes referred to as dimethylethylamine, is an organic compound with formula (CH 3) 2 NC 2 H 5.It is an industrial chemical that is mainly used in foundries as a catalyst for epoxy resins and polyurethane as well as sand core production.