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A generalized tonic–clonic seizure, commonly known as a grand mal seizure or GTCS, [1] is a type of generalized seizure that produces bilateral, convulsive tonic and clonic muscle contractions. Tonic–clonic seizures are the seizure type most commonly associated with epilepsy and seizures in general and the most common seizure associated ...
A seizure is a paroxysmal episode of symptoms or altered behavior arising from abnormal excessive or synchronous brain neuronal activity. [5] A focal onset seizure arises from a biological neural network within one cerebral hemisphere, while a generalized onset seizure arises from within the cerebral hemispheres rapidly involving both hemispheres.
[12] [13] Generalized seizures have been broadly classified into two categories: motor and non-motor. [8] A generalized tonic-clonic seizure (GTCS), also known as a grand mal seizure, is a whole-body seizure that has a tonic phase followed by clonic muscle retrenchments. [14] [15] GTCSs can happen in people of all ages. [15]
Generalized seizures affect both sides of the brain and typically involve both sides of the body. [3] They all involve a loss of consciousness and usually happen without warning. [3] [13] There are six main types of generalized seizures: tonic-clonic, tonic, clonic, myoclonic, absence, and atonic seizures. [3]
Juvenile Myoclonic Epilepsy (JME), also referred to as Janz Syndrome and Impulsive Petit Mal, is a form of epilepsy that is characterized by absence, Myoclonic, and Generalized Tonic-Clonic Seizures. This epilepsy variant is marked by its idiopathic and hereditary characteristics, as well as its generalization across seizures.
Tonic-clonic seizures occur with a contraction of the limbs followed by their extension and arching of the back which lasts 10–30 seconds (the tonic phase). A cry may be heard due to contraction of the chest muscles, followed by a shaking of the limbs in unison (clonic phase). Tonic seizures produce constant contractions of the muscles.
Clonus is typically seen in people with cerebral palsy, stroke, multiple sclerosis, spinal cord damage and hepatic encephalopathy. [2] It can occur in epilepsy as part of a generalized tonic–clonic seizure, and in pregnant women presenting with severe pre-eclampsia and eclampsia. [5]
Progression to hemiconvulsions or generalized tonic-clonic seizures occurs in around half of children and hemiconvulsions may be followed by postictal Todd's hemiparesis. Duration and circadian distribution: Rolandic seizures are usually brief, lasting for 1–3 minutes. Three-quarters of seizures occur during nonrapid eye movement sleep ...