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Schematic of the relation between an immunoglobulin and RAGE Schematic of the RAGE gene and its products. RAGE (receptor for advanced glycation endproducts), also called AGER, is a 35 kilodalton transmembrane receptor [5] of the immunoglobulin super family which was first characterized in 1992 by Neeper et al. [6] Its name comes from its ability to bind advanced glycation endproducts (), which ...
HMGB1 has to interact with p53. [15] [16]HMGB1 is a nuclear protein that binds to DNA and acts as an architectural chromatin-binding factor. It can also be released from cells, in which extracellular form it can bind the inflammatory receptor RAGE (Receptor for Advanced Glycation End-products) and Toll-like receptors (TLRs).
5891 26448 Ensembl ENSG00000080823 ENSMUSG00000056458 UniProt Q9UQ07 Q9WVS4 RefSeq (mRNA) NM_001272011 NM_014226 NM_001330234 NM_001353827 NM_001353828 NM_001353829 NM_001353830 NM_001353831 NM_001353832 NM_011973 RefSeq (protein) NP_001258940 NP_001317163 NP_055041 NP_001340756 NP_001340757 NP_001340758 NP_001340759 NP_001340760 NP_001340761 NP_036103 Location (UCSC) Chr 14: 102.22 – 102.31 ...
Azeliragon (TTP488 or PF-04494700) is a small-molecule RAGE inhibitor. It is developed by vTv Therapeutics for various cancers, including triple-negative breast cancer, [1] [2] pancreatic cancer. [3] The chemical reached Phase III trials in slowing cognitive deterioration in early stage Alzheimer's disease patients.
Once a DAMP is released from the cell, it promotes a noninfectious inflammatory response by binding to a pattern recognition receptor (PRR). [4] Inflammation is a key aspect of the innate immune response; it is used to help mitigate future damage to the organism by removing harmful invaders from the affected area and start the healing process ...
n/a Ensembl ENSG00000163221 n/a UniProt P80511 n/a RefSeq (mRNA) NM_005621 n/a RefSeq (protein) NP_005612 n/a Location (UCSC) Chr 1: 153.37 – 153.38 Mb n/a PubMed search n/a Wikidata View/Edit Human S100 calcium-binding protein A12 (S100A12) is a protein that in humans is encoded by the S100A12 gene. Human S100A12, also known as calgranulin C, was first described in 1995. The protein encoded ...
RAGE (receptor), the biological receptor for advanced glycation endproducts Rage (roller coaster) , a beyond-vertical-drop roller coaster at Adventure Island The Rage (Canada's Wonderland) , a swinging ship ride at Canada's Wonderland
As with many enzymes, RAG proteins are fairly large. For example, mouse RAG-1 contains 1040 amino acids and mouse RAG-2 contains 527 amino acids. The enzymatic activity of the RAG proteins is concentrated largely in a core region; Residues 384–1008 of RAG-1 and residues 1–387 of RAG-2 retain most of the DNA cleavage activity.