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Schematic of the relation between an immunoglobulin and RAGE Schematic of the RAGE gene and its products. RAGE (receptor for advanced glycation endproducts), also called AGER, is a 35 kilodalton transmembrane receptor [5] of the immunoglobulin super family which was first characterized in 1992 by Neeper et al. [6] Its name comes from its ability to bind advanced glycation endproducts (), which ...
Azeliragon (TTP488 or PF-04494700) is a small-molecule RAGE inhibitor. It is developed by vTv Therapeutics for various cancers, including triple-negative breast cancer, [1] [2] pancreatic cancer. [3] The chemical reached Phase III trials in slowing cognitive deterioration in early stage Alzheimer's disease patients.
Paradoxical rage reactions due to benzodiazepines occur as a result of an altered level of consciousness, which generates automatic behaviors, anterograde amnesia and uninhibited aggression. These aggressive reactions may be caused by a disinhibiting serotonergic mechanism. [15]
Kite Pharma, Inc. is an American biotechnology company that develops cancer immunotherapy products with a primary focus on genetically engineered autologous CAR T cell therapy - a cell-based therapy which relies on chimeric antigen receptors and T cells.
Significant events included the launch of AVIPure dsRNA resin, which removes impurities from mRNA-based therapeutics. This move is part of a broader strategy to innovate its product line.
AgeX Therapeutics, Inc. (commonly abbreviated as AgeX Therapeutics or simply AgeX) is an American biotechnology company developing medical therapeutics related to human longevity. It was founded in 2017 by Michael D. West , initially as a subsidiary of BioTime , Inc. with backing from British billionaire investor Jim Mellon and others.
Image source: The Motley Fool. Sarepta Therapeutics (NASDAQ: SRPT) Q4 2024 Earnings Call Feb 26, 2025, 4:30 p.m. ET. Contents: Prepared Remarks. Questions and Answers. Call Participants
Image source: Getty Images. 1. AbbVie. AbbVie (NYSE: ABBV) is a leader in biopharmaceuticals with a product portfolio spanning multiple therapeutic areas, including a strong focus on immunology ...