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Repeated administration of a medication is also different from single dosing, as many drugs have active metabolites that can build up in the body. [6] Patient variables such as sex, age, and organ function may also influence the effect of the drug on the system. These variables are rarely included in equianalgesic charts. [7] [3] [8]
Drug Name Common Trade Names [a] Year Approved Typical Oral Dosage Formulations (mg) Approx. Equivalent Oral Dose to 10 mg Diazepam [b] (mg) Peak Onset of Action (hours) Elimination Half-life of Active Metabolite (hours) Primary Therapeutic Use Adinazolam: Deracyn: Research chemical: 1–2: 3: anxiolytic, antidepressant: Alprazolam
Lorazepam is preferred to other benzodiazepines and zolpidem due to its longer duration of action. [4] An initial therapeutic effect typically occurs within 10–30 minutes of IV administration lorazepam at doses between 2–4 mg. [5] [4] Higher doses may be used in patients who are unresponsive, to minimise the chance of a false negative ...
A box of Lorazepam Orion (Lorazepam) tablets. Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. [14] It is used to treat anxiety (including anxiety disorders), trouble sleeping, severe agitation, active seizures including status epilepticus, alcohol withdrawal, and chemotherapy-induced nausea and vomiting. [14]
Deaths from single-drug benzodiazepine overdoses occur infrequently, [3] particularly after the point of hospital admission. [4] However, combinations of high doses of benzodiazepines with alcohol, barbiturates, opioids or tricyclic antidepressants are particularly dangerous, and may lead to severe complications such as coma or death.
Oral administration of a liquid. In pharmacology and toxicology, a route of administration is the way by which a drug, fluid, poison, or other substance is taken into the body. [1] Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration ...
[8] [120] However, they occur with greater frequency in recreational abusers, individuals with borderline personality disorder, children, and patients on high-dosage regimes. [ 121 ] [ 122 ] In these groups, impulse control problems are perhaps the most important risk factor for disinhibition; learning disabilities and neurological disorders ...
The Tubex system was widely used after World War II and expanded as a system of distributing and administration a large variety of drugs from antibiotics to vaccines in a pre-filled glass cartridge syringe with attached sterile needle. It aided in a standardization of an immediate use sterile dosage forms.
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