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Multiple myeloma is the second-most prevalent blood cancer (10%) after non-Hodgkin's lymphoma. [154] It represents about 1.8% of all new cancers and 2.1% of all cancer deaths. [7] Multiple myeloma affects slightly more men than women.
MR elastography for detection of liver fibrosis in two patients. The left column shows the anatomy, with the liver outlined. The middle row shows images of propagating shear waves in the liver, captured with the MRE technique. The right column shows elastograms computed from the wave images, with tissue stiffness depicted with on color scale.
MPNs arise when precursor cells (blast cells) of the myeloid lineages in the bone marrow develop somatic mutations which cause them to grow abnormally. There is a similar category of disease for the lymphoid lineage, the lymphoproliferative disorders acute lymphoblastic leukemia, lymphomas, chronic lymphocytic leukemia and multiple myeloma. [4]
Transient myeloproliferative disease, renamed Transient Abnormal Myelopoiesis (TAM), [32] is the abnormal proliferation of a clone of noncancerous megakaryoblasts in the liver and bone marrow. The disease is restricted to individuals with Down syndrome or genetic changes similar to those in Down syndrome, develops during pregnancy or shortly ...
Most cases of SPB progress to multiple myeloma within 2–4 years of diagnosis, but the overall median survival for SPB is 7–12 years. 30–50% of extramedullary plasmacytoma cases progress to multiple myeloma with a median time of 1.5–2.5 years. 15–45% of SPB and 50–65% of extramedullary plasmacytoma are disease free after 10 years. [3]
A very common use is the diagnosis of multiple myeloma, where tumour deposits appear as "punched-out" lesions. The standard set of X-rays for a skeletal survey includes X-rays of the skull, entire spine, pelvis, ribs, both humeri and femora (proximal long bones). It is more effective than isotope scans at detecting bone involvement in multiple ...
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