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Nonoxynol-9 is a common ingredient of most vaginal and anal lubricants due to its spermicidal properties. A 2004 study found that over a six-month period, the typical-use failure rates for five nonoxynol-9 vaginal contraceptives (film, suppository, and gels at three different concentrations) ranged from 10% to 20%.
[1] [2] [5] [3] [8] Pharmaceutical gels are formed by adding a gelator (gelling agent) to the solvent [5] [6] and active ingredient mixture. Gelators used in gel formulation can be small molecules with low molecular weight or polymers (synthetic, semi-synthetic or natural).
The condition will even be worsened in some cases. For instance, usage of a topical glucocorticoid gel on fissured hand eczema intensifies the pain as well as stinging because of the alcohol present in the gel. If an ointment is applied on a moist skin injury, it might lead to follicle infection due to the occlusive features of the ointment. [2]
It is still unknown what the results mean for women who would use the product in real-life settings; for example, the effect of sexual intercourse (or semen) on the gel (which often affects the protective properties of a drug) is unknown. The CAPRISA 004 trial demonstrated that topical tenofovir gel provided 51% protection against HSV-2. [12]
Nye Lubricants, Inc. is a manufacturer of industrial lubricants. It formulates, manufactures, and sells synthetic lubricants , thermal coupling compounds, index-matching optical gels, and fluids. Nye supplies the automotive , computer printer , disc drive , mobile appliance, aerospace , defense, and HB- LED OEM markets.
Typically lubricants contain 90% base oil (most often petroleum fractions, called mineral oils) and less than 10% additives. Vegetable oils or synthetic liquids such as hydrogenated polyolefins, esters, silicones, fluorocarbons and many others are sometimes used as base oils.
Tolnaftate [1], sold under the brand name TAGRID, among others, is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, liquid, and liquid aerosol . [ 2 ]
It is injected into the joint capsule, to act as both a shock absorber and a lubricant for the joint. [ 3 ] [ 4 ] [ 5 ] Thus sodium hyaluronate is used as a viscosupplement, administered through a series of injections into the knee , increasing the viscosity of the synovial fluid , which helps lubricate, cushion and reduce pain in the joint. [ 6 ]
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