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Vibrio cholerae is a species of Gram-negative, facultative anaerobe and comma-shaped bacteria. [1] The bacteria naturally live in brackish or saltwater where they attach themselves easily to the chitin -containing shells of crabs, shrimp, and other shellfish.
Cholera toxin (also known as choleragen and sometimes abbreviated to CTX, Ctx or CT) is an AB5 multimeric protein complex secreted by the bacterium Vibrio cholerae. [ 1 ] [ 2 ] CTX is responsible for the massive, watery diarrhea characteristic of cholera infection. [ 3 ]
Prior to the study of V. cholerae, researchers obtained data from a close relative, Vibrio harveyi. Interestingly, the accumulation of autoinducer in colonies of V. cholera decrease LuxO repression on hapR expression. Research seems indicative that hapR plays a role in protecting the cell from virulence factors, thereby helping the cell survive.
Pathogenic Vibrio species include V. cholerae (the causative agent of cholera), V. parahaemolyticus, and V. vulnificus. V. cholerae is generally transmitted by contaminated water. [3] Pathogenic Vibrio species can cause foodborne illness (infection), usually associated with eating undercooked seafood. [18]
Cholera is caused by ingesting a bacteria known as Vibrio cholerae. It's found in contaminated water and food, explains Ivers, which then produces a toxin in the small intestine that leads to the ...
Cholera (/ ˈ k ɒ l ər ə /) is an infection of the small intestine by some strains of the bacterium Vibrio cholerae. [4] [3] Symptoms may range from none, to mild, to severe. [3]The classic symptom is large amounts of watery diarrhea lasting a few days. [2]
The T6SS of Vibrio cholerae has a dual role, being able to target both bacterial and eukaryotic cells. [18] At least one substrate it secretes is specialized for eukaryotic cell-targeting, functioning by cross-linking the cytoskeleton protein actin. [19]
Though the pilgrims failed to show ante or post mortem evidence of cholera, the vibrios isolated agglutinated with the anti-cholera serum. He did not think it was cholera, since it was hemolytic for human and animal red cells, while the true Vibrio cholerae is not. At that time, there was no cholera epidemic in Mecca or at the El Tor station ...