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Famotidine, sold under the brand name Pepcid among others, is a histamine H 2 receptor antagonist medication that decreases stomach acid production. [4] It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome. [4] It is taken by mouth or by injection into a vein. [4] It begins working within ...
Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
A history of heartburn or gastroesophageal reflux disease (GERD) and use of certain medications can raise the suspicion for peptic ulcer. Medicines associated with peptic ulcer include NSAIDs (non-steroidal anti-inflammatory drugs) that inhibit cyclooxygenase and most glucocorticoids (e.g., dexamethasone and prednisolone ).
Histamine 2 antagonists and PPIs have largely replaced antacids as the primary treatment for most acid-peptic disorders; however, they continue to play a role because they are inexpensive, widely available, and safe in the majority of populations. Antacids work almost instantly and are useful for quick relief of mild or sporadic symptoms.
Pepcid RPD Scherer DDS / Merck: yes famotidine: Histamine H2-receptor antagonists [35] duodenal ulcer, gastric ulcer, gastroesophageal reflux disease, pathological hypersecretory conditions adults Prevacid SoluTab Takeda Pharmaceuticals: yes lansoprazole: Proton pump inhibitors [8] Gastro-oesophageal reflux disease (GERD), Ulcers [8] 1 year+ [8]
The GI cocktail is a mixture of a viscous anesthetic, an antacid, and an anticholinergic. [1] [2] Common viscous anesthetics use are viscous lidocaine or xylocaine.Common antacids used are magnesium hydroxide, aluminum hydroxide, or simethicone (more commonly known as Mylanta or Maalox). [3]
Peptic ulcer disease including after endoscopic treatment for bleeding [11] As part of Helicobacter pylori eradication therapy [12] Gastroesophageal reflux disease (GERD or GORD) including symptomatic endoscopy-negative reflux disease [13] and associated laryngopharyngeal reflux causing laryngitis [14] and chronic cough [15] Barrett's esophagus ...
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