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Research in multiple sclerosis may find new pathways to interact with the disease, improve function, curtail attacks, or limit the progression of the underlying disease. Many treatments already in clinical trials involve drugs that are used in other diseases or medications that have not been designed specifically for multiple sclerosis .
Gabriel Steiner (26 May 1883, Ulm – 10 August 1965, Detroit) was a German-American neurologist known for his research of multiple sclerosis.In his studies, he postulated a link between multiple sclerosis and certain forms of spirochetes.
Comparative Effectiveness Research (CER) is an emerging field in Multiple Sclerosis treatment. The response of the disease to the different available medications at this moment cannot be predicted, and would be desirable. [17] But the ideal target is to find subtypes of the disease that respond better to a specific treatment.
The appropriate pathway to put forward masitinib through the regulatory agencies, for the treatment of progressive forms of multiple sclerosis, is under study [34] evobrutinib is a selective oral Bruton's tyrosine kinase (BTK) inhibitor that has been shown to inhibit B-cell activation both in vitro and in vivo. [35] [36] In phase III. [37]
According to Zamboni, CCSVI had a high sensitivity and specificity differentiating healthy individuals from those with multiple sclerosis. [101] Zamboni's results were criticized as some of his studies were not blinded and they need to be verified by further studies. [100] [101] As of 2010 the theory is considered at least defensible [102]
Stephen L. Hauser is a professor of the Department of Neurology at the University of California, San Francisco (UCSF) specializing in immune mechanisms and multiple sclerosis (MS). He has contributed to the establishment of consortia that have identified more than 50 gene variants that contribute to MS risk. [1]
The Multiple Sclerosis Journal (formerly Multiple Sclerosis) is a monthly peer-reviewed medical journal covering the clinical neurology of multiple sclerosis. The editor-in-chief is Alan J Thompson (University College London). It was established in 1995 and is published by SAGE Publications. [1]
Multiple sclerosis can cause a variety of symptoms including changes in sensation (hypoesthesia), muscle weakness, abnormal muscle spasms, impaired movement, difficulties with coordination and balance, problems in speech (known as dysarthria) or swallowing , visual problems (nystagmus, optic neuritis, or diplopia), fatigue and acute or chronic ...