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Evidence suggests that it is the interaction between genes and the environment may be associated with the development of schizophrenia. [2] This is a complex process involving multiple environmental factors that have influence on a range of developmental periods that interact with a genetic susceptibility. [7]
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
An inadequate diet is often found in schizophrenia, and associated vitamin deficiencies including those of folate, and vitamin D are linked to the risk factors for the development of schizophrenia and for early death including heart disease. [225] [226] Those with schizophrenia possibly have the worst diet of all the mental disorders.
Schizophrenia is a debilitating and often misunderstood disorder that affects up to 1% of the world's population. [1] Although schizophrenia is a heavily studied disorder, it has remained largely impervious to scientific understanding; epigenetics offers a new avenue for research, understanding, and treatment.
Having a close family member affected by a mental illness is the largest known risk factor, to date. [6] However, linkage analysis and genome-wide association studies have found few reproducible risk factors. [1] Heterogeneity is an important factor to consider when dealing with genetics. Two types of heterogeneity have been identified in ...
All four of the sisters developed schizophrenia by the age of 24. [2] There was a history of mental illness in Mr. Genain's family that might have been an example of genetics being linked with mental illness or it may have just been a dysfunctional and abusive family free from a specific genetic component.
Risk factors for mental illness include psychological trauma, adverse childhood experiences, genetic predisposition, and personality traits. [7] [8] Correlations between mental disorders and substance use are also found to have a two way relationship, in that substance use can lead to the development of mental disorders and having mental disorders can lead to substance use/abuse.
The implication of genetics in psychiatric illnesses is not unique to schizophrenia, though the heritability of schizophrenia has been calculated as high as 80%. [10] The continued research of the family following the discovery of the translocation yielded statistical analysis of the probability of observing the simultaneous occurrence, or co-inheritance, of psychological conditions and the ...