Search results
Results from the WOW.Com Content Network
Evidence suggests that it is the interaction between genes and the environment may be associated with the development of schizophrenia. [2] This is a complex process involving multiple environmental factors that have influence on a range of developmental periods that interact with a genetic susceptibility. [7]
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
The causes of schizophrenia may include genetic and environmental factors. [7] Genetic factors include a variety of common and rare genetic variants . [ 21 ] Possible environmental factors include being raised in a city , childhood adversity, cannabis use during adolescence, infections, the age of a person's mother or father , and poor ...
Schizophrenia is a debilitating and often misunderstood disorder that affects up to 1% of the world's population. [1] Although schizophrenia is a heavily studied disorder, it has remained largely impervious to scientific understanding; epigenetics offers a new avenue for research, understanding, and treatment.
However, linkage analysis and genome-wide association studies have found few reproducible risk factors. [1] Heterogeneity is an important factor to consider when dealing with genetics. Two types of heterogeneity have been identified in association with psychiatric genetics: causal and clinical.
Risk factors for mental illness include psychological trauma, adverse childhood experiences, genetic predisposition, and personality traits. [7] [8] Correlations between mental disorders and substance use are also found to have a two way relationship, in that substance use can lead to the development of mental disorders and having mental disorders can lead to substance use/abuse.
Genetic variants found due to GWA studies may offer insight concerning impairments in dopaminergic function. [50] Dopamine-related genes linked to psychosis in this way include COMT, DRD4, and AKT1. While genetics play an important role in the occurrence of schizophrenia, other biopsychosocial factors must also be taken into consideration.
Schizophrenia is caused by a combination of genetic and environmental factors. [6] Research illustrates that schizophrenia is hereditary and is more likely to strike those who carry particular genes. [9] It is believed that those who are susceptible to the disorder are affected by something in their environment.