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This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil. Thus, the metabolite is responsible for about 20% of sildenafil's action. Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Sildenafil’s role as a PDE5 inhibitor might help prevent the thickening of heart muscles, a feature that makes it difficult to pump blood. Viagra has also shown real promise for increasing the ...
Viagra (or sildenafil) lasts three to five hours after it’s consumed. Cialis (tadalafil) has a half-life of 17.5 hours, meaning this drug lasts up to 36 hours after it’s consumed.
Like other prescription medicines, Viagra and its generic form, sildenafil, work best when you take them under the right conditions. Like other prescription medicines, Viagra and its generic form ...
Homosildenafil (also known as methyl-sildenafil) is a synthetic drug which acts as a phosphodiesterase inhibitor. [1] It is an analog of sildenafil and vardenafil . Homosildenafil was first identified as an adulterant in sex enhancement products in 2003 and was more recently detected in dietary supplements.
Sildenafil is the active ingredient in the medication and the name for generic Viagra. Viagra and Revatio are the drug’s brand names. Viagra doses range from 25 to 100 milligrams (mg). A typical ...
Vardenafil 4 tablets Blister 20 mg. Vardenafil, sold under the brand name Levitra among others, is a medication that is used for treating erectile dysfunction. [1] [2] It is a PDE5 inhibitor. [1] It is taken by mouth. [1]