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Cell damage (also known as cell injury) is a variety of changes of stress that a cell suffers due to external as well as internal environmental changes. Amongst other causes, this can be due to physical, chemical, infectious, biological, nutritional or immunological factors. Cell damage can be reversible or irreversible.
Cellular stress response is the wide range of molecular changes that cells undergo in response to environmental stressors, including extremes of temperature, exposure to toxins, and mechanical damage. Cellular stress responses can also be caused by some viral infections. [1]
Acidosis (hydrogen cation excess) is an abnormal pH in the body as a result of lactic acidosis which occurs in prolonged hypoxia and in severe infection, diabetic ketoacidosis, kidney failure causing uremia, or ingestion of toxic agents or overdose of pharmacological agents, such as aspirin and other salicylates, ethanol, ethylene glycol and other alcohols, tricyclic antidepressants, isoniazid ...
The relationship between stress and strain is generally linear and reversible up until the yield point and the deformation is elastic. Elasticity in materials occurs when applied stress does not surpass the energy required to break molecular bonds, allowing the material to deform reversibly and return to its original shape once the stress is ...
Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]
Ultimately, doctors stress that a vitamin B12 deficiency and the symptoms that come with it are reversible. “The effects of supplements are often noticed within weeks,” Sachdev says. More on ...
When cyclic stresses are applied to a material, even though the stresses do not cause plastic deformation, the material may fail due to fatigue. Fatigue failure is typically modeled by decomposing cyclic stresses into mean and alternating components. Mean stress is the time average of the principal stress.
[9] [10] Chronic stress, and a lack of coping resources available, or used by an individual, can often lead to the development of psychological issues such as delusions, [11] depression and anxiety (see below for further information). [12] Chronic stress also causes brain atrophy, which is the loss of neurons and the connections between them ...