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Thomas' work showed that bone marrow cells infused intravenously could repopulate the bone marrow and produce new blood cells. His work also reduced the likelihood of developing a life-threatening complication called graft-versus-host disease. [5] The first physician to perform a successful human bone marrow transplant was Robert A. Good.
Lung transplantation is the therapeutic measure of last resort for patients with end-stage lung disease who have exhausted all other available treatments without improvement. A variety of conditions may make such surgery necessary. As of 2005, the most common reasons for lung transplantation in the United States were: [2]
One human clinical case has shown improvements of uterine lining thickness and overall endometrium repair following bone marrow stem cell transplantation. [45] This repair allowed for the patient to successfully become pregnant and carry to term. Additional repairs following bone marrow stem cell transplant to the endometrium include increased ...
Bone marrow transplant can replace the transplant recipient's immune system with the donor's, and the recipient accepts the new organ without rejection. The marrow's hematopoietic stem cells —the reservoir of stem cells replenishing exhausted blood cells including white blood cells forming the immune system—must be of the individual who ...
Less commonly, PTLD occurs after hematopoietic stem cell transplantation. The incidence varies by the type of transplantation: the lowest rates are seen with bone marrow transplants and liver transplants. The highest rates of PTLD are seen with lung and heart transplants, which is primarily due to the need for higher levels of immunosuppression.
Stem-cell transplantation was pioneered using bone marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognized with a Nobel Prize in Physiology or Medicine. Thomas' work showed that bone-marrow cells infused intravenously could ...
Human Cell Atlas; Content; Description: The Human Cell Atlas is a global consortium that is creating detailed maps of the cells in the human body to transform understanding of health and disease. Organisms: Human: Contact; Primary citation: Regev, Aviv; et al. (Human Cell Atlas Organizing Committee) (2018). "The Human Cell Atlas White Paper".
Most cases of acute aspergillosis occur in people with severely compromised immune systems such as those undergoing bone marrow transplantation. [7] Chronic colonization or infection can cause complications in people with underlying respiratory illnesses, such as asthma , [ 8 ] cystic fibrosis , [ 9 ] sarcoidosis , [ 10 ] tuberculosis , or ...
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