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Dermatomyositis is an autoimmune disorder featuring both humoral and T-cell autoimmune processes. [3] Dermatomyositis may develop as a paraneoplastic syndrome associated with several forms of malignancy. [4] It is known to be associated with several viruses, especially coxsackievirus, but no definitive causal link has been found. [3]
Risk factors for severe antisynthetase syndrome include calcinosis, esophageal involvement, cancer, interstitial lung disease without myositis, severe respiratory involvement, and older age at the time of diagnosis. [10] Muscle weakness and arthritis at the point of diagnosis have been noted as favorable outcome measures. [63]
Polymyositis and the associated inflammatory myopathies have an associated increased risk of cancer. [3] The features they found associated with an increased risk of cancer were older age, age greater than 45, male sex, difficulty swallowing, death of skin cells, cutaneous vasculitis, rapid onset of myositis (<4 weeks), elevated creatine kinase, higher erythrocyte sedimentation rate and higher ...
Ultraviolet radiation has been implicated as a potential causative factor in the development of autoimmune diseases, such as dermatomyositis. [43] Furthermore, exposure to pesticides has been linked with an increased risk of developing rheumatoid arthritis. [ 44 ]
Dermatomyositis: Lung cancer in men, breast and gynaecological tumours in women and colorectal cancers in both sexes Scleroderma‐like skin changes Carcinoid syndrome Paraneoplastic pemphigus B‐cell proliferations and thymoma or thymoma‐like neoplasms; specifically Non Hodgkin's lymphoma (42%) Dermatitis herpetiformis: Lymphoma
It can also be associated with underlying cancer. The main classes of idiopathic inflammatory myopathy are polymyositis (PM), dermatomyositis (DM) (including juvenile, amyopathic, and sine-dermatitis form), inclusion-body myositis (IBM), immune-mediated necrotising myopathy (IMNM), and focal autoimmune myositis. [1]
The report also called out different rates of risk factors among different races and ethnic groups. Black women were found to have the highest rate of obesity (57.9%) and Asian women had the ...
Gottron's sign is a pathognomonic cutaneous manifestation associated with dermatomyositis (DM), which is an inflammatory disorder affecting the skin and muscles. [1] The primary lesion of dermatomyositis appears as a violaceous, macular erythema with a symmetric distribution, which may progress and become poikilodermatous (atrophic with telangiectasia and pigmentary changes) and indurated (as ...