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The common biomolecular mechanisms underlying addiction – CREB and ΔFosB – were reviewed by Eric J. Nestler in a 2013 review. [3] Genetics and mental disorders may precipitate the severity of a drug addiction. It is estimated that 50% of healthy individuals developing an addiction can trace the cause to genetic factors. [4]
Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption ...
The latter reflects physical dependence in which the body adapts to the drug, requiring more of it to achieve a certain effect (tolerance) [25] and eliciting drug-specific physical or mental symptoms if drug use is abruptly ceased (withdrawal). Physical dependence can happen with the chronic use of many drugs—including even appropriate ...
"Substance use pertains to using select substances such as alcohol, tobacco, illicit drugs, etc. that can cause dependence or harmful side effects."On the other hand, substance abuse is the use of drugs such as prescriptions, over-the-counter medications, or alcohol for purposes other than what they are intended for or using them in excessive ...
Drug addiction has been shown to work in phenomenological, conditioning (operant and classical), cognitive models, and the cue reactivity model. However, no one model completely illustrates substance abuse. [33] Risk factors for addiction include: Aggressive behavior (particularly in childhood) Availability of substance [31]
Personality theories of addiction are psychological models that associate personality traits or modes of thinking (i.e., affective states) with an individual's proclivity for developing an addiction. Models of addiction risk that have been proposed in psychology literature include an affect dysregulation model of positive and negative ...
Lindesmith's work on drugs began with his questioning of the nature of addiction in a 1938 essay entitled "A sociological theory of drug addiction".This paper appeared in the American Journal of Sociology and involved in-depth interviews with 50 so-called addicts.
The cognitive urge and automaticity model is a prominent cognitive theory of addiction and purposes that behaviors associated with substance administration become automatic and cues can trigger such automatized behaviors. [2] This model is consistent with addiction models that emphasize habit-like processes.