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  2. Histidine - Wikipedia

    en.wikipedia.org/wiki/Histidine

    In catalytic triads, the basic nitrogen of histidine abstracts a proton from serine, threonine, or cysteine to activate it as a nucleophile. In a histidine proton shuttle, histidine is used to quickly shuttle protons. It can do this by abstracting a proton with its basic nitrogen to make a positively charged intermediate and then use another ...

  3. Catalytic triad - Wikipedia

    en.wikipedia.org/wiki/Catalytic_triad

    Histidine is thus able to act as a powerful general base, activating the serine nucleophile. The histidine base aids the first leaving group by donating a proton, and also activates the hydrolytic water substrate by abstracting a proton as the remaining OH − attacks the acyl-enzyme intermediate.

  4. APOBEC3A - Wikipedia

    en.wikipedia.org/wiki/APOBEC3A

    In such motifs, histidine residues (or cysteine residues in RNA cytidine deaminases) coordinate the zinc ion while a glutamic acid stabilizes the transition state and the proton shuttle. The zinc ion, in this case, is specifically coordinated by residues H70, C101 and C106. [7] [8] [9] [10]

  5. Malate dehydrogenase - Wikipedia

    en.wikipedia.org/wiki/Malate_dehydrogenase

    The three residues in particular that comprise a catalytic triad are histidine (His-195), aspartate (Asp-168), both of which work together as a proton transfer system, and arginines (Arg-102, Arg-109, Arg-171), which secure the substrate.

  6. Enzyme catalysis - Wikipedia

    en.wikipedia.org/wiki/Enzyme_catalysis

    Proton donors and acceptors, i.e. acids and base may donate and accept protons in order to stabilize developing charges in the transition state. This is related to the overall principle of catalysis, that of reducing energy barriers, since in general transition states are high energy states, and by stabilizing them this high energy is reduced ...

  7. Hidden Uses for Common Household Products Most People Don't ...

    www.aol.com/finance/hidden-uses-common-household...

    1. Tennis Ball. Tennis balls are so useful that you may want to buy some to keep around the house even if you don’t play. For example, half a tennis ball can help screw open tight caps.

  8. Two-component regulatory system - Wikipedia

    en.wikipedia.org/.../Two-component_regulatory_system

    Two-component systems accomplish signal transduction through the phosphorylation of a response regulator (RR) by a histidine kinase (HK). Histidine kinases are typically homodimeric transmembrane proteins containing a histidine phosphotransfer domain and an ATP binding domain, though there are reported examples of histidine kinases in the atypical HWE and HisKA2 families that are not ...

  9. Colorado snow forecast: Multiple feet expected in the Rockies ...

    www.aol.com/colorado-snow-forecast-multiple-feet...

    Editor's note: Follow USA TODAY's Wednesday coverage of the Thanksgiving 2024 weather forecast and travel updates.. Heavy snow showers of 1 to 2 feet are expected to blanket in the Colorado ...