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  2. Murine leukemia virus - Wikipedia

    en.wikipedia.org/wiki/Murine_leukemia_virus

    MLV reverse transcriptases are thought to have a slightly higher fidelity than the HIV-1 RT. ... Reverse transcriptase from MMLV is used in biotechnology; References

  3. Reverse transcriptase - Wikipedia

    en.wikipedia.org/wiki/Reverse_transcriptase

    A reverse transcriptase (RT) is an enzyme used to convert RNA genome to DNA, a process termed reverse transcription.Reverse transcriptases are used by viruses such as HIV and hepatitis B to replicate their genomes, by retrotransposon mobile genetic elements to proliferate within the host genome, and by eukaryotic cells to extend the telomeres at the ends of their linear chromosomes.

  4. Template-switching polymerase chain reaction - Wikipedia

    en.wikipedia.org/wiki/Template-switching...

    Template-switching polymerase chain reaction (TS-PCR) is a method of reverse transcription and polymerase chain reaction (PCR) amplification that relies on a natural PCR primer sequence at the polyadenylation site, also known as the poly(A) tail, and adds a second primer through the activity of murine leukemia virus reverse transcriptase. [1]

  5. Reverse transcription polymerase chain reaction - Wikipedia

    en.wikipedia.org/wiki/Reverse_transcription...

    Once a one-step RT-PCR kit with a mix of reverse transcriptase, Taq DNA polymerase, and a proofreading polymerase is selected and all necessary materials and equipment are obtained a reaction mix is to be prepared. The reaction mix includes dNTPs, primers, template RNA, necessary enzymes, and a buffer solution.

  6. Prime editing - Wikipedia

    en.wikipedia.org/wiki/Prime_editing

    As a comparison, an SpCas9-reverse transcriptase fusion protein is 6.3kb, [1] [23] which does not even account for the lengthened guide RNA necessary for targeting and priming the site of interest. However, successful delivery in mice has been achieved by splitting the editor into two AAV vectors [ 2 ] [ 3 ] [ 4 ] [ 24 ] or by using an ...

  7. Reverse Transcription Loop-mediated Isothermal Amplification

    en.wikipedia.org/wiki/Reverse_Transcription_Loop...

    This conversion is made by a reverse transcriptase, an enzyme derived from retroviruses capable of making such a conversion. [15] This DNA derived from RNA is called cDNA, or complementary DNA. The FIP primer is used by the reverse transcriptase to build a single-strand of copy DNA. The F3 primer binds to this side of the template strand as ...

  8. Complementary DNA - Wikipedia

    en.wikipedia.org/wiki/Complementary_DNA

    The M-MLV reverse transcriptase from the Moloney murine leukemia virus is commonly used due to its reduced RNase H activity suited for transcription of longer RNAs. [11] The AMV reverse transcriptase from the avian myeloblastosis virus may also be used for RNA templates with strong secondary structures (i.e. high melting temperature).

  9. Retroviral ribonuclease H - Wikipedia

    en.wikipedia.org/wiki/Retroviral_ribonuclease_H

    The retroviral ribonuclease H (retroviral RNase H) is a catalytic domain of the retroviral reverse transcriptase (RT) enzyme. The RT enzyme is used to generate complementary DNA from the retroviral RNA genome. This process is called reverse transcription. To complete this complex process, the retroviral RT enzymes need to adopt a ...

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