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Hepatosplenomegaly (commonly abbreviated HSM) is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly).Hepatosplenomegaly can occur as the result of acute viral hepatitis, infectious mononucleosis, and histoplasmosis or it can be the sign of a serious and life-threatening lysosomal storage disease.
Patients with lymphocytic interstitial pneumonia may present with lymphadenopathy, enlarged liver, enlarged spleen, enlarged salivary gland, thickening and widening of the extremities of the fingers and toes , and breathing symptoms such as shortness of breath and wheezing.
Splenomegaly is an enlargement of the spleen. [1] The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen.Splenomegaly is one of the four cardinal signs of hypersplenism which include: some reduction in number of circulating blood cells affecting granulocytes, erythrocytes or platelets in any combination; a compensatory proliferative response in the bone marrow; and the ...
Portal vein thrombosis causes upper abdominal pain, possibly accompanied by nausea and an enlarged liver and/or spleen; the abdomen may be filled with fluid (). [3]A persistent fever may result from the generalized inflammation. [1]
However, he questioned if it was a rare genetic condition called Gaucher disease, which involves a buildup of fatty cells in the liver, spleen, and occasionally the bone marrow. (This happens ...
Enlarged liver and grossly enlarged spleen (together hepatosplenomegaly) are common; [3] the spleen can rupture and cause additional complications. Skeletal weakness and bone disease may be extensive. [3] Spleen enlargement and bone marrow replacement cause anemia, thrombocytopenia, and leukopenia.
It presents in these diseases as the onset of progressive enlargements of the liver and spleen, worsening liver dysfunction, new skin rashes, pancytopenia (i.e. falls in the blood levels of leukocytes, red blood cells, and platelets), hemophagocytosis (i.e. ingestion of blood cells by histiocytes) in bone marrow and spleen), a coagulopathy ...
These typically won’t cause pain or grow, so because I’m asymptomatic, no action is necessary. ... Liver (they can see if the liver is enlarged or it’s a fatty liver) ... Spleen. Adrenals ...